PMID- 11121200
OWN - NLM
STAT- MEDLINE
DCOM- 20001228
LR  - 20190906
IS  - 0148-7299 (Print)
IS  - 0148-7299 (Linking)
VI  - 96
IP  - 6
DP  - 2000 Dec 4
TI  - Human leukocyte antigen (HLA) DRB1 alleles in Kuwaiti Arabs with schizophrenia.
PG  - 870-2
AB  - The frequency of human leukocyte anti- gen DRB1 alleles was determined in a 
      cohort of 194 Kuwaiti Arabs consisting of 80 schizophrenia patients and 114 
      ethnically matched healthy controls, using a polymerase chain reaction-sequence 
      specific primers method. A total of 12 DRB1 alleles were identified in this 
      Kuwaiti cohort. A statistically significant difference was detected in the 
      frequency of alleles DRB1(*)04 and DRB1(*)13 between the schizophrenia patients 
      and controls. Allele frequency of DRB1(*)04 in schizophrenia patients was 14% 
      compared with nearly 7% in controls (P = 0.028). For DRB1(*)13, the allele 
      frequency was found to be 18% in schizophrenia patients compared with 9% in the 
      controls (P = 0.015). For alleles, DRB1(*)03, DRB1(*)07, and DRB1(*)16 the 
      frequency was higher in controls compared with schizophrenia patients. The 
      frequency of DRB1(*)01, DRB1(*)08, DRB1(*)10, DRB1(*)11, and DRB1(*)15 alleles 
      was almost identical in schizophrenia patients and controls. For the remaining 
      alleles, the differences between the two groups were not statistically 
      significant. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:870-872, 2000.
CI  - Copyright 2000 Wiley-Liss, Inc.
FAU - Haider, M Z
AU  - Haider MZ
AD  - Clinical Genetics Group, Pediatrics Department, Faculty of Medicine, Kuwait 
      University of Kuwait, Kuwait. haider@hsc.kuniv.edu.kw
FAU - Zahid, M A
AU  - Zahid MA
FAU - Dalal, H N
AU  - Dalal HN
FAU - Razik, M A
AU  - Razik MA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Med Genet
JT  - American journal of medical genetics
JID - 7708900
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Alleles
MH  - Arabs/*genetics
MH  - DNA/genetics
MH  - Female
MH  - Gene Frequency
MH  - Genotype
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Kuwait
MH  - Male
MH  - Middle Aged
MH  - Schizophrenia/*genetics
EDAT- 2000/12/20 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/12/20 11:00
PHST- 2000/12/20 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/12/20 11:00 [entrez]
AID - 10.1002/1096-8628(20001204)96:6<870::AID-AJMG36>3.0.CO;2-L [pii]
AID - 10.1002/1096-8628(20001204)96:6<870::aid-ajmg36>3.0.co;2-l [doi]
PST - ppublish
SO  - Am J Med Genet. 2000 Dec 4;96(6):870-2. doi: 
      10.1002/1096-8628(20001204)96:6<870::aid-ajmg36>3.0.co;2-l.