PMID- 11123053
OWN - NLM
STAT- MEDLINE
DCOM- 20010405
LR  - 20191104
IS  - 1523-3774 (Print)
IS  - 1523-3774 (Linking)
VI  - 2
IP  - 2
DP  - 2000 Apr
TI  - Non-HIV retroviral associations with rheumatic disease.
PG  - 156-62
AB  - While the human T-cell lymphotropic virus type I (HTLV-I) is the recognized cause 
      of adult T cell leukemia, it is also associated with non-neoplastic, ostensibly 
      autoimmune conditions, such as tropical spastic paraparesis. Moreover,among 
      carriers of HTLV-I, the virus is strongly implicated in the development of a type 
      of arthritis, which resembles rheumatoid arthritis (RA). Mice transgenic for 
      HTLV-I tax develop RA-like pathology and Sjogren's syndrome. Patients with RA and 
      SS in HTLV-I nonendemic regions, such as the United States, are usually 
      serologically negative for antibodies to the structural proteins of HTLV. 
      However, they appear to harbor HTLV-I tax in their peripheral blood mononuclear 
      cells three times as often as individuals who present as healthy blood donors. 
      Because HTLV-I tax transactivates numerous inflammatory cytokines and is not 
      normally found in the human genome, treatment with tax antisense oligonucleotides 
      may provide a new therapeutic approach for selected RA patients proven to be 
      HTLV-I "tax only" positive.
FAU - Zucker-Franklin, D
AU  - Zucker-Franklin D
AD  - Professor of Medicine, Department of Medicine, New York University Medical 
      Center, Tisch Hospital, Room TH 445, 550 First Avenue, New York, NY 10016, USA.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Rheumatol Rep
JT  - Current rheumatology reports
JID - 100888970
SB  - IM
MH  - Adult
MH  - Animals
MH  - Arthritis, Rheumatoid/*epidemiology/immunology/*virology
MH  - Autoimmune Diseases/diagnosis/*epidemiology/immunology
MH  - Comorbidity
MH  - Deltaretrovirus Infections/diagnosis/*epidemiology/immunology
MH  - Disease Models, Animal
MH  - Female
MH  - Human T-lymphotropic virus 1/genetics/*isolation & purification
MH  - Humans
MH  - Male
MH  - Mice
MH  - Mice, Transgenic
MH  - Prognosis
MH  - Risk Assessment
MH  - Sensitivity and Specificity
RF  - 71
EDAT- 2000/12/21 11:00
MHDA- 2001/04/06 10:01
CRDT- 2000/12/21 11:00
PHST- 2000/12/21 11:00 [pubmed]
PHST- 2001/04/06 10:01 [medline]
PHST- 2000/12/21 11:00 [entrez]
AID - 10.1007/s11926-000-0056-0 [doi]
PST - ppublish
SO  - Curr Rheumatol Rep. 2000 Apr;2(2):156-62. doi: 10.1007/s11926-000-0056-0.