PMID- 11123072
OWN - NLM
STAT- MEDLINE
DCOM- 20020225
LR  - 20191104
IS  - 1523-3774 (Print)
IS  - 1523-3774 (Linking)
VI  - 2
IP  - 4
DP  - 2000 Aug
TI  - Animal models of the spondyloarthropathies.
PG  - 282-7
AB  - Several lines of rats transgenic for human leukocyte antigen (HLA)-B27 
      spontaneously develop a multisystemic inflammatory disease resembling human 
      spondyloarthropathies. This disease is mediated by cells of the immune system and 
      is dependent on the presence of a normal bacterial flora. Both antigen-presenting 
      cells expressing high levels of HLA-B27 and T cells appear to be of importance in 
      the pathogenesis of this model. HLA-B27 transgenic/b2- microglobulin deficient 
      mice also develop arthritis, under the influence of the bacterial flora. In both 
      types of model, CD8+ T cells appear to be unnecessary, arguing against the 
      "arthritogenic peptide" hypothesis.
FAU - Breban, M
AU  - Breban M
AD  - INSERM U477 and Service de Rhumatologie B, Hopital Cochin, AP-HP, Universite Rene 
      Descartes, 27 rue du Faubourg Saint-Jacques, 75014 Paris, France.
FAU - Falgarone, G
AU  - Falgarone G
FAU - Blanchard, H
AU  - Blanchard H
FAU - Dernis-Labous, E
AU  - Dernis-Labous E
FAU - Lamarque, D
AU  - Lamarque D
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Curr Rheumatol Rep
JT  - Current rheumatology reports
JID - 100888970
RN  - 0 (HLA-B27 Antigen)
SB  - IM
MH  - Animals
MH  - Animals, Genetically Modified
MH  - Arthritis, Reactive/etiology/immunology
MH  - Bacteria/immunology
MH  - Cross Reactions
MH  - *Disease Models, Animal
MH  - HLA-B27 Antigen/immunology
MH  - Humans
MH  - Mice
MH  - Mice, Transgenic
MH  - Rats
MH  - Rats, Inbred F344
MH  - Rats, Inbred Lew
MH  - *Spondylarthropathies/etiology/immunology
MH  - T-Lymphocytes/immunology
EDAT- 2000/12/21 11:00
MHDA- 2002/02/28 10:01
CRDT- 2000/12/21 11:00
PHST- 2000/12/21 11:00 [pubmed]
PHST- 2002/02/28 10:01 [medline]
PHST- 2000/12/21 11:00 [entrez]
AID - 10.1007/s11926-000-0064-0 [doi]
PST - ppublish
SO  - Curr Rheumatol Rep. 2000 Aug;2(4):282-7. doi: 10.1007/s11926-000-0064-0.