PMID- 11123074
OWN - NLM
STAT- MEDLINE
DCOM- 20020225
LR  - 20191104
IS  - 1523-3774 (Print)
IS  - 1523-3774 (Linking)
VI  - 2
IP  - 4
DP  - 2000 Aug
TI  - T-cell studies in the spondyloarthropathies.
PG  - 297-305
AB  - A growing body of evidence suggests that T lymphocytes play an important role in 
      initiating and maintaining the inflammatory process characteristic of the human 
      leukocyte antigen (HLA)-B27-associated spondyloarthropathies. T cells seem to be 
      involved in the primary defense reaction against arthritis-triggering 
      gram-negative bacteria at the site of extra-articular infection, in determining 
      the systemic cytokine pattern, in the recirculation process between gut mucosa 
      and the joint, and in mediating secondary autoimmune joint inflammation. The 
      factors involved in disease chronicity (namely in ankylosing spondylitis and 
      psoriatic arthritis) are still unknown. Autoreactive T cells may contribute to 
      this process by recognition of cross-reactive self-epitopes (ie, molecular 
      mimicry between bacterial and self-antigens). Autoreactive T cells may as well be 
      inappropriately upregulated by bacterial superantigens, or by local inflammatory 
      reactions leading to the uncovering of former cryptic self-epitopes. In this 
      paper, we review recent studies on peripheral blood and synovial T cells in 
      patients with reactive arthritis, enteropathic spondyloarthropathy, psoriatic 
      arthritis, and ankylosing spondylitis.
FAU - Marker-Hermann, E
AU  - Marker-Hermann E
AD  - Department of Internal Medicine, Johannes Gutenberg-University of Mainz, 
      Langenbeckstr. 1, D - 55101 Mainz, Germany. emaerker@mail.uni-mainz.de
FAU - Schwab, P
AU  - Schwab P
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Rheumatol Rep
JT  - Current rheumatology reports
JID - 100888970
RN  - 0 (CD4 Antigens)
RN  - 0 (CD8 Antigens)
RN  - 0 (Epitopes)
RN  - 0 (HLA-B27 Antigen)
SB  - IM
MH  - Arthritis, Psoriatic/immunology
MH  - Arthritis, Reactive/immunology
MH  - CD4 Antigens/immunology
MH  - CD8 Antigens/immunology
MH  - Cross Reactions
MH  - Epitopes
MH  - HLA-B27 Antigen/immunology
MH  - Humans
MH  - Inflammation/immunology
MH  - Inflammatory Bowel Diseases/complications
MH  - Spondylarthropathies/etiology/*immunology
MH  - Spondylitis, Ankylosing/immunology
MH  - T-Lymphocytes/*immunology
RF  - 61
EDAT- 2000/12/21 11:00
MHDA- 2002/02/28 10:01
CRDT- 2000/12/21 11:00
PHST- 2000/12/21 11:00 [pubmed]
PHST- 2002/02/28 10:01 [medline]
PHST- 2000/12/21 11:00 [entrez]
AID - 10.1007/s11926-000-0066-y [doi]
PST - ppublish
SO  - Curr Rheumatol Rep. 2000 Aug;2(4):297-305. doi: 10.1007/s11926-000-0066-y.