PMID- 11123075
OWN - NLM
STAT- MEDLINE
DCOM- 20020225
LR  - 20211203
IS  - 1523-3774 (Print)
IS  - 1523-3774 (Linking)
VI  - 2
IP  - 4
DP  - 2000 Aug
TI  - Probing for genes in seronegative spondyloarthropathy.
PG  - 306-10
AB  - Seronegative spondyloarthropathies are a group of disorders characterized by 
      inflammation of the spine, sacroiliac joints, and peripheral arthritis along with 
      various characteristic extra-articular features. Their pathogenesis and 
      immunogenetics have not yet been fully elucidated. Ankylosing Spondylitis (AS) is 
      probably the best studied of these disease. It has now been 27 years since the 
      association of human leukocyte antigen (HLA) B27 and AS has been demonstrated. 
      Since then, a plethora of association studies and linkage studies unequivocally 
      demonstrate that genetic determinants within or near the major histocompatible 
      complex (MHC) are critical to the etiology of AS. Surprisingly though, the total 
      MHC contribution to AS has been estimated at only 30%. In this review, we 
      highlight the genetic basis of AS as the prototypical chronic axial arthritis, 
      and discuss the rationale and approach in searching for non-HLA linked genes.
FAU - Stone, M
AU  - Stone M
AD  - Departments of Medicine and Immunology, University of Toronto, Division of 
      Rheumatology, Toronto Western Hospital, Toronto, Canada.
FAU - Khraishi, M M
AU  - Khraishi MM
FAU - Rahman, P
AU  - Rahman P
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Rheumatol Rep
JT  - Current rheumatology reports
JID - 100888970
RN  - 0 (Genetic Markers)
RN  - 0 (HLA-B27 Antigen)
SB  - IM
MH  - Diseases in Twins/genetics
MH  - Ethnicity
MH  - Female
MH  - Genetic Linkage
MH  - Genetic Markers
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA-B27 Antigen/genetics
MH  - Haplotypes
MH  - Humans
MH  - Major Histocompatibility Complex/genetics
MH  - Male
MH  - Microsatellite Repeats
MH  - Phenotype
MH  - Risk
MH  - Spondylarthropathies/etiology/*genetics
MH  - Spondylitis, Ankylosing/etiology/genetics
MH  - Twins, Dizygotic
MH  - Twins, Monozygotic
RF  - 38
EDAT- 2000/12/21 11:00
MHDA- 2002/02/28 10:01
CRDT- 2000/12/21 11:00
PHST- 2000/12/21 11:00 [pubmed]
PHST- 2002/02/28 10:01 [medline]
PHST- 2000/12/21 11:00 [entrez]
AID - 10.1007/s11926-000-0067-x [doi]
PST - ppublish
SO  - Curr Rheumatol Rep. 2000 Aug;2(4):306-10. doi: 10.1007/s11926-000-0067-x.