PMID- 11124518
OWN - NLM
STAT- MEDLINE
DCOM- 20010201
LR  - 20211203
IS  - 0301-0171 (Print)
IS  - 0301-0171 (Linking)
VI  - 90
IP  - 3-4
DP  - 2000
TI  - Aneuploidy in human sperm: a review of the frequency and distribution of 
      aneuploidy, effects of donor age and lifestyle factors.
PG  - 219-26
AB  - Application of fluorescence in situ hybridization (FISH) analysis has opened the 
      way for comprehensive studies on numerical chromosome abnormalities in human 
      sperm. During the last decade, more than five million sperm from approximately 
      500 normal men were analyzed by a number of laboratories from around the world by 
      this approach. Except for chromosome 19 which has been analyzed in only one 
      study, all other chromosomes have been examined by two or more studies with 
      considerable differences in disomy frequency for an individual chromosome among 
      studies. The mean disomy frequency is 0.15% for each of the autosomes and 0.26% 
      for the sex chromosomes. Most chromosomes analyzed have an equal distribution of 
      disomy with the exception of chromosomes 14, 21, 22 and the sex chromosomes, 
      which display significantly higher disomy frequencies. Slight but significant 
      increases in disomy frequency with advancing paternal age were observed for some 
      chromosomes, in particular for the sex chromosomes. Some lifestyle factors such 
      as smoking, alcohol drinking and caffeine consumption have been investigated and 
      no consistent association between disomy frequency and any type of lifestyle 
      factors has been established. The question of whether different geographic and 
      ethnic groups of men have inherent differences in frequency of disomic sperm has 
      been investigated by two studies with conflicting results.
CI  - Copyright 2000 S. Karger AG, Basel.
FAU - Shi, Q
AU  - Shi Q
AD  - Department of Medical Genetics, Faculty of Medicine, University of Calgary, 
      Alberta Children's Hospital, Calgary, Alberta, Canada.
FAU - Martin, R H
AU  - Martin RH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Switzerland
TA  - Cytogenet Cell Genet
JT  - Cytogenetics and cell genetics
JID - 0367735
SB  - IM
MH  - *Aneuploidy
MH  - Chromosomes, Human/genetics
MH  - Ethnicity/genetics
MH  - Gene Frequency/*genetics
MH  - Geography
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - *Life Style
MH  - Male
MH  - *Paternal Age
MH  - Spermatozoa/*metabolism
RF  - 87
EDAT- 2000/12/22 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/12/22 11:00
PHST- 2000/12/22 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/12/22 11:00 [entrez]
AID - 56773 [pii]
AID - 10.1159/000056773 [doi]
PST - ppublish
SO  - Cytogenet Cell Genet. 2000;90(3-4):219-26. doi: 10.1159/000056773.