PMID- 11124840
OWN - NLM
STAT- MEDLINE
DCOM- 20010201
LR  - 20111117
IS  - 0270-9139 (Print)
IS  - 0270-9139 (Linking)
VI  - 33
IP  - 1
DP  - 2001 Jan
TI  - HLA class II genes determine the natural variance of hepatitis C viral load.
PG  - 224-30
AB  - The aim of this study was to investigate the relationship between human leukocyte 
      antigen (HLA) class II genes and the natural fluctuations in hepatitis C viral 
      load in a homogeneous patient population. The study group consisted of 57 viremic 
      (hepatitis C virus [HCV] 1b) women for whom HLA class II DRB1 and DQB1 
      haplotyping, virologic, histologic, and biochemical markers of disease activity 
      were available. All patients were infected with HCV 1b from the same source of 
      hepatitis C-contaminated anti-D immunoglobulin during the period from May 1977 to 
      November 1978. The mean slope of change of viral load was 0.34 (SD +/- 0.73) 
      log(10) viral copies/mL/year, which is significantly different from zero, P < 
      10(-9). Analysis of the relationship between the slope of change of viral load 
      and HLA class II haplotype indicated a significantly different slope of change of 
      viral load between the alleles of (1) DRB1(*)15 and DRB1(*)0701, and (2) 
      DQB1(*)0602 and DQB1(*)0201, P(c) =.036 and P(c) =.026 after Bonferroni 
      correction for multiple comparisons, respectively. Significant differences for 
      grade and stage of disease at liver biopsy were observed for DQB1(*)0501 and 
      DQB1(*)0201 alleles; P =.019, r(s) =.64, and P =.047, r(s) =.57, respectively. In 
      addition, significant differences in stage of disease were found to exist between 
      DRB1(*)13 and DRB1(*)0701, P =.031, r(s) = -.71. Our results define an 
      association between the slope of change of viral load and HLA class II haplotype 
      in patients infected with genotype 1b of HCV. This suggests a role for host 
      immunogenetic factors in HCV infection in this homogeneous group.
FAU - Fanning, L J
AU  - Fanning LJ
AD  - Hepatitis C Unit, Department of Medicine, National University of Ireland, Cork. 
      L.FANNING@UCC.IE
FAU - Levis, J
AU  - Levis J
FAU - Kenny-Walsh, E
AU  - Kenny-Walsh E
FAU - Whelton, M
AU  - Whelton M
FAU - O'Sullivan, K
AU  - O'Sullivan K
FAU - Shanahan, F
AU  - Shanahan F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Hepatology
JT  - Hepatology (Baltimore, Md.)
JID - 8302946
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Cohort Studies
MH  - Female
MH  - HLA-DQ Antigens/genetics
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/genetics
MH  - HLA-DRB1 Chains
MH  - Haplotypes
MH  - Hepatitis C/*genetics/immunology/*virology
MH  - Histocompatibility Antigens Class II/*genetics
MH  - Humans
MH  - Viral Load
MH  - Viremia/genetics/immunology/virology
EDAT- 2000/12/22 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/12/22 11:00
PHST- 2000/12/22 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/12/22 11:00 [entrez]
AID - S0270-9139(01)49208-1 [pii]
AID - 10.1053/jhep.2001.20642 [doi]
PST - ppublish
SO  - Hepatology. 2001 Jan;33(1):224-30. doi: 10.1053/jhep.2001.20642.