PMID- 11127447
OWN - NLM
STAT- MEDLINE
DCOM- 20010111
LR  - 20190708
IS  - 0735-1097 (Print)
IS  - 0735-1097 (Linking)
VI  - 36
IP  - 7
DP  - 2000 Dec
TI  - Results of partial left ventriculectomy for dilated cardiomyopathy: hemodynamic, 
      clinical and echocardiographic observations.
PG  - 2098-103
AB  - OBJECTIVES: The study was done to prospectively measure the echocardiographic, 
      hemodynamic and clinical outcomes after partial left ventriculectomy (PLV). 
      BACKGROUND: Although PLV can improve symptoms of advanced heart failure, 
      immediate postoperative echocardiographic findings remain abnormal. METHODS: 
      Fifty-nine patients with cardiomyopathy and advanced heart failure underwent PLV 
      and concomitant mitral valve surgery between May 1996 and December 1997. 
      Thirty-nine percent were on inotropic therapy. All were New York Heart 
      Association (NYHA) functional class III or IV. Mechanical circulatory support 
      (LVAD) and transplant were provided for rescue therapy when hemodynamic 
      compromise occurred. Patients were followed for a mean of 405+/-168 days, and 
      clinical, echocardiographic and hemodynamic measures were obtained 
      preoperatively, immediately postoperatively, and at 3 and 12 months 
      prospectively. RESULTS: Comparing preoperative and 12-month postoperative values 
      in event-free survivors, we found: NYHA functional class improved from 3.6 to 
      2.1, p < 0.0001; peak oxygen consumption increased from 10.8 to 16.0 ml/kg/min, p 
      < 0.0001; LV ejection fraction increased from 13+/-6.0% to 24+/-6.9%, p < 0.0001; 
      LV end diastolic diameter decreased from 8.2+/-1.03 to 6.2+/-0.64 cm, p < 0.0001, 
      and volume was reduced from 167+/-60 to 105+/-38 ml/m2, p = 0.02. Central 
      hemodynamics did not normalize after surgery. CONCLUSIONS: Partial left 
      ventriculectomy can provide structural remodeling of the heart that may result in 
      temporary improvement in clinical compensation. However, perioperative failures 
      and the return of heart failure limit the propriety of this procedure.
FAU - Starling, R C
AU  - Starling RC
AD  - George M. and Linda H. Kaufman Center for Heart Failure, Department of 
      Cardiology, Cleveland Clinic Foundation, Ohio 44195, USA. starlir@ccf.org
FAU - McCarthy, P M
AU  - McCarthy PM
FAU - Buda, T
AU  - Buda T
FAU - Wong, J
AU  - Wong J
FAU - Goormastic, M
AU  - Goormastic M
FAU - Smedira, N G
AU  - Smedira NG
FAU - Thomas, J D
AU  - Thomas JD
FAU - Blackstone, E H
AU  - Blackstone EH
FAU - Young, J B
AU  - Young JB
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Am Coll Cardiol
JT  - Journal of the American College of Cardiology
JID - 8301365
SB  - IM
CIN - J Am Coll Cardiol. 2000 Dec;36(7):2115-8. PMID: 11127449
CIN - J Am Coll Cardiol. 2001 Jul;38(1):286. PMID: 11451288
MH  - Aged
MH  - Cardiomyopathy, Dilated/diagnostic imaging/physiopathology/*surgery
MH  - Female
MH  - Heart Ventricles/*surgery
MH  - Hemodynamics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Treatment Outcome
MH  - Ultrasonography
MH  - Ventricular Remodeling
EDAT- 2000/12/29 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/12/29 11:00
PHST- 2000/12/29 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/12/29 11:00 [entrez]
AID - S0735-1097(00)01034-2 [pii]
AID - 10.1016/s0735-1097(00)01034-2 [doi]
PST - ppublish
SO  - J Am Coll Cardiol. 2000 Dec;36(7):2098-103. doi: 10.1016/s0735-1097(00)01034-2.