PMID- 11128661
OWN - NLM
STAT- MEDLINE
DCOM- 20010208
LR  - 20161124
IS  - 0315-162X (Print)
IS  - 0315-162X (Linking)
VI  - 27
IP  - 12
DP  - 2000 Dec
TI  - Serum matrix metalloproteinase 3 in early rheumatoid arthritis is correlated with 
      disease activity and radiological progression.
PG  - 2761-8
AB  - OBJECTIVE: To analyze the clinical significance of serial measurements of serum 
      matrix metalloproteinase 3 (MMP-3) levels in relation to markers of disease 
      activity and radiological progression in early rheumatoid arthritis (RA). 
      METHODS: In a 3 year prospective study of 33 patients with early RA (symptoms < 1 
      year at entry) monthly measurements of serum MMP-3 were transformed into time 
      integrated values for 6 month periods for comparison with other markers of 
      disease activity like swollen joint count (SJC), tender joint count (TJC), 
      Ritchie articular index (RAI), the disease activity score (DAS), erythrocyte 
      sedimentation rate (ESR), C-reactive protein (CRP), and radiological progression, 
      scored according to Sharp's method, in which erosions and joint space narrowing 
      are scored separately and combined to a total Sharp score. RESULTS: Significant 
      correlations were found between serum MMP-3 and SJC, ESR, and CRP during all 
      periods and between 6 and 30 months with the DAS. There were no correlations 
      between serum MMP-3 and TJC or the RAI. During the first 12 months serum MMP-3 
      was correlated only with the item joint space narrowing of the Sharp score. After 
      12 months of followup it was also correlated with the total Sharp score and after 
      18 months it was correlated with all 3 items of the Sharp score. There was a wide 
      interindividual variation in the relation between serum MMP-3 and radiological 
      progression but intraindividually this relation seemed to be rather constant. 
      CONCLUSION: Time integrated values of serum MMP-3 are correlated with time 
      integrated values of other markers of disease activity such as joint swelling, 
      ESR, CRP, and the DAS. Of the radiological scores, as outcome measures, 
      especially joint space narrowing correlated closely with cumulative serum MMP-3.
FAU - Posthumus, M D
AU  - Posthumus MD
AD  - Department of Rheumatology, University Hospital Groningen, Groningen, The 
      Netherlands. m.posthumus@int.azg.nl
FAU - Limburg, P C
AU  - Limburg PC
FAU - Westra, J
AU  - Westra J
FAU - van Leeuwen, M A
AU  - van Leeuwen MA
FAU - van Rijswijk, M H
AU  - van Rijswijk MH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Canada
TA  - J Rheumatol
JT  - The Journal of rheumatology
JID - 7501984
RN  - 0 (Biomarkers)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Arthritis, Rheumatoid/*blood/diagnostic imaging/enzymology
MH  - Biomarkers/blood
MH  - Cohort Studies
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Male
MH  - Matrix Metalloproteinase 3/*blood
MH  - Middle Aged
MH  - Prospective Studies
MH  - Radiography
EDAT- 2000/12/29 11:00
MHDA- 2001/03/03 10:01
CRDT- 2000/12/29 11:00
PHST- 2000/12/29 11:00 [pubmed]
PHST- 2001/03/03 10:01 [medline]
PHST- 2000/12/29 11:00 [entrez]
PST - ppublish
SO  - J Rheumatol. 2000 Dec;27(12):2761-8.