PMID- 11128714
OWN - NLM
STAT- MEDLINE
DCOM- 20010222
LR  - 20181130
IS  - 1050-7256 (Print)
IS  - 1050-7256 (Linking)
VI  - 10
IP  - 11
DP  - 2000 Nov
TI  - Treatment of a thyrotropinoma with octreotide-LAR in a patient with multiple 
      endocrine neoplasia-1.
PG  - 1001-7
AB  - OBJECTIVE: To note that a thyrotropin (TSH)-secreting macroadenoma may be part of 
      the multiple endocrine neoplasia-1 (MEN-1) syndrome and to report the use of 
      octreotide-LAR (OCT-LAR) to treat a TSH-secreting macroadenoma in a patient with 
      MEN-1 with previous surgery for hyperparathyroidism and gastrinoma. METHODS: We 
      present a patient with a TSH-secreting pituitary macroadenoma and report the 
      results of her endocrine, genetic, radiologic, and nuclear medicine testing and 
      her response to treatment with octreotide (OCT), octreotide-LAR, and estrogen. 
      RESULTS: This patient's TSH-induced hyperthyroidism responded to octreotide for 5 
      months and octreotide-LAR for more than 11 months. Her hypercalcemia normalized 
      while she was taking estrogen. Her genetic testing is reported to show a genetic 
      defect that is typical of patients with MEN-1. CONCLUSION: This report describes: 
      (1) The use of octreotide-LAR to treat both a TSH-secreting pituitary tumor and a 
      gastrinoma over 12 months; (2) the importance of including these tumors into the 
      MEN-1 syndrome with its attendant implications; and (3) a genetic defect, typical 
      of patients with MEN-1, associated with this tumor.
FAU - Taylor, T J
AU  - Taylor TJ
AD  - Diabetes and Metabolic Disease Center, Christiana Health Systems, Wilmington, 
      Delaware, USA. rathmines2@yahoo.com
FAU - Donlon, S S
AU  - Donlon SS
FAU - Bale, A E
AU  - Bale AE
FAU - Smallridge, R C
AU  - Smallridge RC
FAU - Francis, T B
AU  - Francis TB
FAU - Christensen, R S
AU  - Christensen RS
FAU - Burma, K D
AU  - Burma KD
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Thyroid
JT  - Thyroid : official journal of the American Thyroid Association
JID - 9104317
RN  - 0 (Estrogens)
RN  - 0 (Hormones)
RN  - 9002-71-5 (Thyrotropin)
RN  - RWM8CCW8GP (Octreotide)
SB  - IM
MH  - Adenoma/diagnostic imaging/*drug therapy/metabolism
MH  - Estrogens/administration & dosage
MH  - Female
MH  - Hormones/*administration & dosage
MH  - Humans
MH  - Hypercalcemia/etiology
MH  - Hyperthyroidism/diagnostic imaging/drug therapy/etiology
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/diagnostic imaging/*drug therapy
MH  - Octreotide/*administration & dosage
MH  - Radionuclide Imaging
MH  - Thyroid Neoplasms/diagnostic imaging/*drug therapy/metabolism
MH  - Thyrotropin/*metabolism
EDAT- 2000/12/29 11:00
MHDA- 2001/03/03 10:01
CRDT- 2000/12/29 11:00
PHST- 2000/12/29 11:00 [pubmed]
PHST- 2001/03/03 10:01 [medline]
PHST- 2000/12/29 11:00 [entrez]
AID - 10.1089/thy.2000.10.1001 [doi]
PST - ppublish
SO  - Thyroid. 2000 Nov;10(11):1001-7. doi: 10.1089/thy.2000.10.1001.