PMID- 11129442
OWN - NLM
STAT- MEDLINE
DCOM- 20010222
LR  - 20191104
IS  - 1052-9551 (Print)
IS  - 1052-9551 (Linking)
VI  - 9
IP  - 4
DP  - 2000 Dec
TI  - Increased incidence of trisomy 8 in acute myeloid leukemia with skin infiltration 
      (leukemia cutis).
PG  - 190-4
AB  - Anecdotal literature reports and the authors' own observations suggest an 
      association between chromosome 8 aneuploidy and leukemia cutis. The authors 
      investigated this potential association by using fluorescence in situ 
      hybridization (FISH) directly on skin infiltrates in a series of 11 patients with 
      acute monocytic leukemia (AML). Seven of the 11 patients were aneuploid for 
      chromosome 8 by FISH which was confirmed by dual color hybridization. Six of 
      these seven patients were AML-M4 or M5 and one was M1. The majority of the cases 
      with leukemia cutis expressed CD4 (90% of cases), CD14 (60%), and/or CD56 (50%) 
      in bone marrow leukemic cells. The data show the utility of examination of skin 
      infiltrates by FISH for the detection of trisomy 8 in leukemia cutis. They also 
      suggest the importance of trisomy 8 as a factor in predisposition to skin 
      infiltration in AML.
FAU - Sen, F
AU  - Sen F
AD  - Department of Pathology, Duke University Medical Center, Durham, North Carolina, 
      USA.
FAU - Zhang, X X
AU  - Zhang XX
FAU - Prieto, V G
AU  - Prieto VG
FAU - Shea, C R
AU  - Shea CR
FAU - Qumsiyeh, M B
AU  - Qumsiyeh MB
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Diagn Mol Pathol
JT  - Diagnostic molecular pathology : the American journal of surgical pathology, part 
      B
JID - 9204924
SB  - IM
MH  - Chromosomes, Human, Pair 8/*genetics
MH  - Female
MH  - Flow Cytometry
MH  - Humans
MH  - Immunophenotyping
MH  - In Situ Hybridization, Fluorescence
MH  - Incidence
MH  - Karyotyping
MH  - Leukemia, Myeloid, Acute/epidemiology/*genetics/pathology
MH  - Leukemic Infiltration/*genetics
MH  - Male
MH  - Retrospective Studies
MH  - Skin/*pathology
MH  - Trisomy/*genetics
EDAT- 2000/12/29 11:00
MHDA- 2001/03/03 10:01
CRDT- 2000/12/29 11:00
PHST- 2000/12/29 11:00 [pubmed]
PHST- 2001/03/03 10:01 [medline]
PHST- 2000/12/29 11:00 [entrez]
AID - 10.1097/00019606-200012000-00003 [doi]
PST - ppublish
SO  - Diagn Mol Pathol. 2000 Dec;9(4):190-4. doi: 10.1097/00019606-200012000-00003.