PMID- 11129872 OWN - NLM STAT- MEDLINE DCOM- 20010222 LR - 20190605 IS - 0916-7250 (Print) IS - 0916-7250 (Linking) VI - 62 IP - 11 DP - 2000 Nov TI - Experimental sensitization with Japanese cedar pollen in dogs. PG - 1223-5 AB - Japanese cedar pollinosis is a type I allergic disease mediated by immunoglobulin E (IgE) antibodies to Japanese cedar (Cryptomeria japonica) pollen antigen (CPAg). By using 22 dogs consisting of 20 dogs aged 3 months and 2 dogs aged 3 years, immunization was performed by subcutaneous injections of CPAg with aluminum hydroxide gel. Variable levels of CPAg-specific IgE antibody response were detected in 21 of the 22 immunized dogs two weeks after the second immunization. This study provided an experimental sensitization system with CPAg in dogs, which will be useful for further immunological studies on Japanese cedar pollinosis. FAU - Yamashita, K AU - Yamashita K AD - Pharmaceutical Research Laboratory, Hitachi Chemical Co., Ltd., Ibaraki, Japan. FAU - Masuda, K AU - Masuda K FAU - Sakaguchi, M AU - Sakaguchi M FAU - Odagiri, T AU - Odagiri T FAU - Nakao, Y AU - Nakao Y FAU - Yamaki, M AU - Yamaki M FAU - Hasegawa, A AU - Hasegawa A FAU - Matsuo, Y AU - Matsuo Y FAU - Deboer, D J AU - Deboer DJ FAU - Ohno, K AU - Ohno K FAU - Tsujimoto, H AU - Tsujimoto H LA - eng PT - Journal Article PL - Japan TA - J Vet Med Sci JT - The Journal of veterinary medical science JID - 9105360 RN - 37341-29-0 (Immunoglobulin E) SB - IM MH - Animals MH - Antibody Formation MH - Cycadopsida MH - Dogs MH - Female MH - Hypersensitivity/immunology/*veterinary MH - Immunization/*veterinary MH - Immunoglobulin E/*blood MH - Japan MH - Male MH - Pollen/*immunology MH - Trees EDAT- 2000/12/29 11:00 MHDA- 2001/03/03 10:01 CRDT- 2000/12/29 11:00 PHST- 2000/12/29 11:00 [pubmed] PHST- 2001/03/03 10:01 [medline] PHST- 2000/12/29 11:00 [entrez] AID - 10.1292/jvms.62.1223 [doi] PST - ppublish SO - J Vet Med Sci. 2000 Nov;62(11):1223-5. doi: 10.1292/jvms.62.1223.