PMID- 11130886
OWN - NLM
STAT- MEDLINE
DCOM- 20010208
LR  - 20061115
IS  - 0146-6615 (Print)
IS  - 0146-6615 (Linking)
VI  - 63
IP  - 1
DP  - 2001 Jan
TI  - Human herpesvirus 6 infection in neoplastic and normal brain tissue.
PG  - 45-51
AB  - The presence and variant distribution of human herpesvirus 6 (HHV-6) was 
      investigated by a nested polymerase chain reaction (PCR) in 118 biopsies from 
      patients affected by nervous tissue tumor (115 primary tumors and 3 metastasis) 
      and in 31 autopsy samples from the brain of healthy individuals. HHV-6 DNA 
      sequences were detected in normal and neoplastic nervous tissue at a frequency of 
      32% and 37%, respectively. In both tissues, variant A was three times more 
      frequent than the variant B. Peripheral blood lymphocytes (PBLs) derived from 
      seven tumor affected patients contained the same variant as their respective 
      brain sample, as judged by PCR. The expression of HHV-6 encoded immediate early 
      protein p41 was detected by immunohistochemistry in neoplastic but not in normal 
      brain. This may reflect viral reactivation from latency in immunocompromised 
      patients. The seroepidemiological data indicated a frequency distribution of 
      anti-HHV-6 antibodies in patients with brain tumors similar to that found in 
      healthy donors.
FAU - Cuomo, L
AU  - Cuomo L
AD  - Istituto Neurologico Mediterraneo Neuromed, Pozzilli, Italy.
FAU - Trivedi, P
AU  - Trivedi P
FAU - Cardillo, M R
AU  - Cardillo MR
FAU - Gagliardi, F M
AU  - Gagliardi FM
FAU - Vecchione, A
AU  - Vecchione A
FAU - Caruso, R
AU  - Caruso R
FAU - Calogero, A
AU  - Calogero A
FAU - Frati, L
AU  - Frati L
FAU - Faggioni, A
AU  - Faggioni A
FAU - Ragona, G
AU  - Ragona G
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Med Virol
JT  - Journal of medical virology
JID - 7705876
RN  - 0 (Antibodies, Viral)
RN  - 0 (Antigens, Viral)
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Antibodies, Viral/blood
MH  - Antigens, Viral/analysis
MH  - Brain/*virology
MH  - Brain Neoplasms/immunology/*secondary/virology
MH  - DNA, Viral/analysis
MH  - Herpesviridae Infections/*virology
MH  - Herpesvirus 6, Human/genetics/*isolation & purification
MH  - Humans
MH  - Immunohistochemistry
MH  - Leukocytes, Mononuclear/virology
EDAT- 2000/12/29 11:00
MHDA- 2001/03/03 10:01
CRDT- 2000/12/29 11:00
PHST- 2000/12/29 11:00 [pubmed]
PHST- 2001/03/03 10:01 [medline]
PHST- 2000/12/29 11:00 [entrez]
AID - 10.1002/1096-9071(200101)63:1<45::AID-JMV1006>3.0.CO;2-K [pii]
PST - ppublish
SO  - J Med Virol. 2001 Jan;63(1):45-51.