PMID- 11132177
OWN - NLM
STAT- MEDLINE
DCOM- 20010215
LR  - 20190814
IS  - 0024-4201 (Print)
IS  - 0024-4201 (Linking)
VI  - 35
IP  - 11
DP  - 2000 Nov
TI  - Polyunsaturated fatty acids in plasma lipids of obese children with and without 
      metabolic cardiovascular syndrome.
PG  - 1179-84
AB  - Previously we reported significantly higher values of gamma-linolenic acid (GLA, 
      18:3n-6), dihomo-gamma-linolenic acid (DHGLA, 20:3n-6), and arachidonic acid 
      (20:4n-6) in plasma lipid classes in obese children than in nonobese controls. In 
      the present study, fatty acid composition of plasma phospholipids (PL) and sterol 
      esters (STE) was determined by high-resolution capillary gas-liquid 
      chromatography in obese children with and without metabolic cardiovascular 
      syndrome [MCS: defined as simultaneous presence of (i) dyslipidemia, (ii) 
      hyperinsulinemia, (iii) hypertension, and.(iv) impaired glucose tolerance] and in 
      nonobese controls. Fatty acid composition of PL and STE lipids did not differ 
      between obese children without MCS and controls. Obese children with MCS 
      exhibited significantly lower linoleic acid (LA, 18:2n-6) values in PL (17.43 
      [2.36], % wt/wt, median [range from the first to the third quartile]) than obese 
      children without MCS (19.14 [3.49]) and controls (20.28 13.80]). In contrast, PL 
      GLA values were significantly higher in obese children with (0.13 [0.08]) than in 
      those without MCS (0.08 [0.04]), whereas STE GLA values were higher in obese 
      children with MCS (1.04 [0.72]) than in controls (0.62 [0.48]). DHGLA values in 
      PL were significantly higher in obese children with MCS (4.06 [0.74]) than in 
      controls (2.69 [1.60]). The GLA/LA ratio was significantly higher, whereas the 
      AA/DHGLA ratio was significantly lower in obese children with MCS than in obese 
      children without MCS and in controls. In this study, LA metabolism was affected 
      only in obese children with but not in those without MCS. In obese children with 
      MCS, delta6-desaturase activity appeared to be stimulated, whereas 
      delta5-desaturase activity appeared to be inhibited. Disturbances in LA 
      metabolism may represent an additional health hazard within the multifaceted 
      clinical picture of MCS.
FAU - Decsi, T
AU  - Decsi T
AD  - Department of Paediatrics, University of Pecs, Hungary. decsi@apacs.pote.hu
FAU - Csabi, G
AU  - Csabi G
FAU - Torok, K
AU  - Torok K
FAU - Erhardt, E
AU  - Erhardt E
FAU - Minda, H
AU  - Minda H
FAU - Burus, I
AU  - Burus I
FAU - Molnar, S
AU  - Molnar S
FAU - Molnar, D
AU  - Molnar D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Lipids
JT  - Lipids
JID - 0060450
RN  - 0 (Fatty Acids, Unsaturated)
RN  - 0 (Lipids)
SB  - IM
MH  - Adolescent
MH  - Case-Control Studies
MH  - Child
MH  - Chromatography, Gas
MH  - Fatty Acids, Unsaturated/*blood
MH  - Female
MH  - Humans
MH  - Lipids/*blood/chemistry
MH  - Male
MH  - Microvascular Angina/*blood
MH  - Obesity/*blood
EDAT- 2000/12/29 11:00
MHDA- 2001/03/03 10:01
CRDT- 2000/12/29 11:00
PHST- 2000/12/29 11:00 [pubmed]
PHST- 2001/03/03 10:01 [medline]
PHST- 2000/12/29 11:00 [entrez]
AID - 10.1007/s11745-000-0634-7 [doi]
PST - ppublish
SO  - Lipids. 2000 Nov;35(11):1179-84. doi: 10.1007/s11745-000-0634-7.