PMID- 11134105
OWN - NLM
STAT- MEDLINE
DCOM- 20010202
LR  - 20221207
IS  - 0021-972X (Print)
IS  - 0021-972X (Linking)
VI  - 85
IP  - 12
DP  - 2000 Dec
TI  - Common susceptibility and transmission pattern of human leukocyte antigen 
      DRB1-DQB1 haplotypes to Korean and Caucasian patients with type 1 diabetes.
PG  - 4538-42
AB  - The incidence of type 1 diabetes in Korea is less than 1/10th of that in the 
      United States, and it has been suggested that human leukocyte antigen (HLA) 
      alleles of Asian patients associated with diabetes differ from those of 
      Caucasians. In this study we analyzed the common susceptibility and transmission 
      pattern of a series of HLA DRB1-DQB1 haplotypes to Korean and Caucasian patients 
      with type 1 diabetes. We performed HLA DR and DQ typing of 158 type 1 diabetic 
      patients in a case control study, 140 nondiabetic subjects from the same 
      geographical area, 49 simplex families from Seoul, and 283 families from the 
      Human Biological Data Interchange. Although the haplotype frequencies in the two 
      populations are quite different, when identical haplotypes are compared, their 
      odds ratios are nearly the same. For all parental haplotypes, the transmission to 
      diabetic offspring was similar for Korean and Caucasian families (r = 0.8; P: < 
      10(-)(4)). Allowing for ethnic differences in allelic associations due to 
      different frequencies of DRB1 and DQB1 haplotypes (linkage disequilibrium), these 
      data show, not only by case-control comparison but also by transmission analyses 
      of the haplotypes, that the susceptibility effects of DRB1-DQB1 haplotypes are 
      consistent in Koreans and Caucasians. Thus, the influence of class II 
      susceptibility and resistance alleles appears to transcend ethnic and geographic 
      diversity of type 1 diabetes.
FAU - Park, Y
AU  - Park Y
AD  - Barbara Davis Center for Childhood Diabetes, University of Colorado Health 
      Sciences Center, Denver, Colorado 80262, USA.
FAU - She, J X
AU  - She JX
FAU - Wang, C Y
AU  - Wang CY
FAU - Lee, H
AU  - Lee H
FAU - Babu, S
AU  - Babu S
FAU - Erlich, H A
AU  - Erlich HA
FAU - Noble, J A
AU  - Noble JA
FAU - Eisenbarth, G S
AU  - Eisenbarth GS
LA  - eng
GR  - DK32083/DK/NIDDK NIH HHS/United States
GR  - DK50220/DK/NIDDK NIH HHS/United States
GR  - DK53103/DK/NIDDK NIH HHS/United States
GR  - etc.
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQbeta antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Asian People
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 1/*genetics
MH  - Female
MH  - Genes, MHC Class II/genetics
MH  - Genotype
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Haplotypes
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Risk Factors
MH  - White People
EDAT- 2001/01/03 11:00
MHDA- 2001/03/03 10:01
CRDT- 2001/01/03 11:00
PHST- 2001/01/03 11:00 [pubmed]
PHST- 2001/03/03 10:01 [medline]
PHST- 2001/01/03 11:00 [entrez]
AID - 10.1210/jcem.85.12.7024 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2000 Dec;85(12):4538-42. doi: 10.1210/jcem.85.12.7024.