PMID- 11134584
OWN - NLM
STAT- MEDLINE
DCOM- 20010301
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 887
IP  - 1
DP  - 2000 Dec 22
TI  - Medial prefrontal transection enhances social interaction. I: behavioral studies.
PG  - 7-15
AB  - Behavioral effects of a medial prefrontal cortex (MPFC) transection were assessed 
      in animal tests of anxiety. Social investigation and plus-maze open arm 
      exploration increased in MPFC damaged animals relative to sham ones. MPFC lesions 
      prevented D-amphetamine (2 mg/kg, i.p.) induced social investigation decrease and 
      exaggerated general locomotion increase. Diazepam (1 mg/kg, i.p.) and MPFC 
      synergistically increased open arm exploration on a second (repeated) plus-maze 
      trial. These results suggest that the MPFC would be implicated in a generalized 
      mechanism of warning enabling emission of appropriate responses to anxiogenic 
      stimuli. Although, this lesion did not modify motor activity itself, the pattern 
      of the motor activation induced by amphetamine was altered. The role of the MPFC 
      areas in the behavioral response associated with fear is discussed.
FAU - Gonzalez, L E
AU  - Gonzalez LE
AD  - Laboratory of Behavioral Physiology, Department of Physiology, School of 
      Medicine, Los Andes University, Merida, Venezuela. gorey@ing.ula.ve
FAU - Rujano, M
AU  - Rujano M
FAU - Tucci, S
AU  - Tucci S
FAU - Paredes, D
AU  - Paredes D
FAU - Silva, E
AU  - Silva E
FAU - Alba, G
AU  - Alba G
FAU - Hernandez, L
AU  - Hernandez L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Anti-Anxiety Agents)
RN  - 0 (Central Nervous System Stimulants)
RN  - Q3JTX2Q7TU (Diazepam)
RN  - TZ47U051FI (Dextroamphetamine)
SB  - IM
MH  - Animals
MH  - Anti-Anxiety Agents/pharmacology
MH  - Central Nervous System Stimulants/pharmacology
MH  - Dextroamphetamine/pharmacology
MH  - Diazepam/pharmacology
MH  - *Interpersonal Relations
MH  - Male
MH  - Motor Activity/drug effects/*physiology
MH  - Prefrontal Cortex/drug effects/injuries/*physiology
MH  - Rats
MH  - Rats, Wistar
EDAT- 2001/01/03 11:00
MHDA- 2001/03/07 10:01
CRDT- 2001/01/03 11:00
PHST- 2001/01/03 11:00 [pubmed]
PHST- 2001/03/07 10:01 [medline]
PHST- 2001/01/03 11:00 [entrez]
AID - S0006-8993(00)02931-0 [pii]
AID - 10.1016/s0006-8993(00)02931-0 [doi]
PST - ppublish
SO  - Brain Res. 2000 Dec 22;887(1):7-15. doi: 10.1016/s0006-8993(00)02931-0.