PMID- 11134686 OWN - NLM STAT- MEDLINE DCOM- 20010222 LR - 20190712 IS - 0031-9384 (Print) IS - 0031-9384 (Linking) VI - 71 IP - 1-2 DP - 2000 Oct 1-15 TI - Prenatal exposure to methylazoxymethanol acetate in the rat alters neurotrophin levels and behavior: considerations for neurodevelopmental diseases. PG - 57-67 AB - We did a single injection of methylazoxymethanol acetate (MAM) in pregnant rats on gestational day (GD) 11 or 12 to investigate the long-lasting effects of early entorhinal cortex (EC) and hippocampus maldevelopment on behavior, brain nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) levels, and the neurotrophin receptor p75 and choline acetyltransferase (ChAT) immunoreactivity. Adult animals treated with MAM had compromised EC development and showed changes in locomotion and displacement activities. In addition, rats treated on GD 12 had increased concentration of NGF and BDNF in the EC and hippocampus if compared to control rats. Prenatal MAM administration did not affect significantly p75 and ChAT distribution in the EC and septum. Results are discussed in reference to the neurodevelopmental hypothesis of psychiatric disorders. FAU - Fiore, M AU - Fiore M AD - Institute of Neurobiology, CNR, viale Marx, 43/15, 00137, Rome, Italy. FAU - Korf, J AU - Korf J FAU - Angelucci, F AU - Angelucci F FAU - Talamini, L AU - Talamini L FAU - Aloe, L AU - Aloe L LA - eng PT - Journal Article PL - United States TA - Physiol Behav JT - Physiology & behavior JID - 0151504 RN - 0 (Adaptor Proteins, Signal Transducing) RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Nerve Growth Factors) RN - 0 (Psip1 protein, rat) RN - 0 (Teratogens) RN - 0 (Trans-Activators) RN - 0 (Transcription Factors) RN - 592-62-1 (Methylazoxymethanol Acetate) RN - EC 2.3.1.6 (Choline O-Acetyltransferase) SB - IM MH - Adaptor Proteins, Signal Transducing MH - Animals MH - Behavior, Animal/*drug effects MH - Brain Chemistry/drug effects MH - Brain-Derived Neurotrophic Factor/metabolism MH - Choline O-Acetyltransferase/metabolism MH - Entorhinal Cortex/drug effects/growth & development MH - Enzyme-Linked Immunosorbent Assay MH - Female MH - Hippocampus/drug effects/growth & development MH - Interpersonal Relations MH - Methylazoxymethanol Acetate/*pharmacology MH - Nerve Growth Factors/*metabolism MH - Pregnancy MH - Prenatal Exposure Delayed Effects MH - Rats MH - Rats, Wistar MH - Teratogens/*pharmacology MH - Trans-Activators/metabolism MH - Transcription Factors EDAT- 2001/01/03 11:00 MHDA- 2001/03/03 10:01 CRDT- 2001/01/03 11:00 PHST- 2001/01/03 11:00 [pubmed] PHST- 2001/03/03 10:01 [medline] PHST- 2001/01/03 11:00 [entrez] AID - S0031-9384(00)00310-3 [pii] AID - 10.1016/s0031-9384(00)00310-3 [doi] PST - ppublish SO - Physiol Behav. 2000 Oct 1-15;71(1-2):57-67. doi: 10.1016/s0031-9384(00)00310-3.