PMID- 11136879
OWN - NLM
STAT- MEDLINE
DCOM- 20010201
LR  - 20190513
IS  - 1462-0324 (Print)
IS  - 1462-0324 (Linking)
VI  - 39
IP  - 12
DP  - 2000 Dec
TI  - Synovial fluid matrix metalloproteinase-3 levels are increased in inflammatory 
      arthritides whether erosive or not.
PG  - 1357-65
AB  - OBJECTIVE: To study the levels of matrix metalloproteinase-3 (MMP-3) in the knee 
      synovial fluid (SF) of inflammatory arthropathies (rheumatoid arthritis whether 
      erosive or not, reactive arthritis, acute crystal arthritis) and degenerative 
      arthropathies [chronic crystal disease, osteoarthritis and (control) meniscus 
      pathology] and to correlate them with the degree of joint destruction, local 
      inflammatory and immune parameters and systemic markers of inflammation. METHODS: 
      SF levels of MMP-3 (precursor, active and tissue inhibitor of MMP-bound forms), 
      tumour necrosis factor (TNF) alpha, soluble TNF receptors I and II, interleukin 
      (IL)-6 and soluble IL-6 receptor were measured by ELISA in 107 inflammatory and 
      53 degenerative arthropathies. RESULTS: MMP-3 levels in SF were (i) significantly 
      higher in inflammatory than in degenerative arthropathies; (ii) not related to 
      the degree of joint destruction; (iii) significantly correlated with the levels 
      of all SF markers tested and with erythrocyte sedimentation rate and serum levels 
      of C-reactive protein and fibrinogen. CONCLUSION: Increased MMP-3 levels in SF 
      are found in inflammatory arthropathies and are not specific for erosive joint 
      diseases. MMP-3 in SF is therefore a potential candidate for the assessment of 
      the inflammatory process in joints. However, the exclusive determination of the 
      active form could indicate the degree of joint destruction.
FAU - Ribbens, C
AU  - Ribbens C
AD  - Rheumatology Department, University Hospital of Liege, CHU Sart-Tilman B35, 
      B-4000 Liege, Belgium.
FAU - Andre, B
AU  - Andre B
FAU - Kaye, O
AU  - Kaye O
FAU - Kaiser, M J
AU  - Kaiser MJ
FAU - Bonnet, V
AU  - Bonnet V
FAU - Jaspar, J M
AU  - Jaspar JM
FAU - de Groote, D
AU  - de Groote D
FAU - Franchimont, N
AU  - Franchimont N
FAU - Malaise, M G
AU  - Malaise MG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Rheumatology (Oxford)
JT  - Rheumatology (Oxford, England)
JID - 100883501
RN  - 0 (Biomarkers)
RN  - 9001-32-5 (Fibrinogen)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Arthritis, Reactive/*enzymology/physiopathology
MH  - Arthritis, Rheumatoid/*enzymology/physiopathology
MH  - Biomarkers/analysis
MH  - Blood Sedimentation
MH  - C-Reactive Protein/analysis
MH  - Female
MH  - Fibrinogen/analysis
MH  - Humans
MH  - Male
MH  - Matrix Metalloproteinase 3/*analysis/metabolism
MH  - Middle Aged
MH  - Synovial Fluid/enzymology
EDAT- 2001/01/04 11:00
MHDA- 2001/02/28 10:01
CRDT- 2001/01/04 11:00
PHST- 2001/01/04 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2001/01/04 11:00 [entrez]
AID - 10.1093/rheumatology/39.12.1357 [doi]
PST - ppublish
SO  - Rheumatology (Oxford). 2000 Dec;39(12):1357-65. doi: 
      10.1093/rheumatology/39.12.1357.