PMID- 11141332
OWN - NLM
STAT- MEDLINE
DCOM- 20010222
LR  - 20061115
IS  - 1521-6616 (Print)
IS  - 1521-6616 (Linking)
VI  - 98
IP  - 1
DP  - 2001 Jan
TI  - Inverse relationship between neopterin and immunoglobulin E.
PG  - 104-8
AB  - Polarized human T helper (Th) cells play a key role in the network of the 
      specific immune system compartments. Cell-mediated immune response depends on 
      activation of Th1-type cells, typically producing and releasing interferon-gamma 
      and interleukin-2, whereas activation of Th2-type cells and production of 
      cytokines such as interleukin-4, -5, and -10 are involved in humoral immune 
      response and the production of immunoglobulins. Increased amounts of neopterin 
      are produced during the Th1-type immune response by human monocytes/macrophages 
      upon stimulation with the Th1-derived cytokine interferon-gamma, and thus the 
      determination of neopterin concentrations allows us to monitor Th1-type immune 
      response. We compared serum concentrations of neopterin with immunoglobulin E 
      (IgE), a typical product of the Th2-type immune response, in order to examine the 
      relationship between Th1-type and Th2-type immune system stimulation in 709 
      healthy outpatients, who visited the physician's office for a medical health 
      checkup. Eleven percent presented with serum neopterin concentrations >8.7 
      nmol/L; 26% had increased serum concentrations of IgE (>100 kIU/L). There existed 
      an inverse correlation between serum neopterin and IgE concentrations (Spearman's 
      rank correlation coefficient: r(s) = -0.100; P < 0.01) which was stronger when 
      excluding data < or = 8.7 nmol/L neopterin and < or = 100 kIU/L IgE (n = 246; 
      r(s) = -0.519; P < 0.0001). Data indicate that increased serum neopterin 
      concentrations are associated with low serum IgE and increased serum IgE with low 
      serum neopterin concentrations. This finding fully agrees with the current 
      understanding that in humans the activation of Th1 and Th2 cell-mediated immune 
      responses are down-regulating each other.
CI  - Copyright 2001 Academic Press.
FAU - Ledochowski, M
AU  - Ledochowski M
AD  - Department of Internal Medicine, Leopold Franzens University, Innsbruck, Austria.
FAU - Murr, C
AU  - Murr C
FAU - Widner, B
AU  - Widner B
FAU - Fuchs, D
AU  - Fuchs D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Clin Immunol
JT  - Clinical immunology (Orlando, Fla.)
JID - 100883537
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 670-65-5 (Neopterin)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antibody Formation
MH  - Child
MH  - Female
MH  - Humans
MH  - Hypersensitivity, Immediate/blood
MH  - Immunoglobulin E/*blood
MH  - Least-Squares Analysis
MH  - Linear Models
MH  - Male
MH  - Middle Aged
MH  - Neopterin/*blood
MH  - Skin Tests
MH  - Th1 Cells/immunology
MH  - Th2 Cells/immunology
EDAT- 2001/01/06 11:00
MHDA- 2001/03/03 10:01
CRDT- 2001/01/06 11:00
PHST- 2001/01/06 11:00 [pubmed]
PHST- 2001/03/03 10:01 [medline]
PHST- 2001/01/06 11:00 [entrez]
AID - S1521-6616(00)94952-0 [pii]
AID - 10.1006/clim.2000.4952 [doi]
PST - ppublish
SO  - Clin Immunol. 2001 Jan;98(1):104-8. doi: 10.1006/clim.2000.4952.