PMID- 11145352
OWN - NLM
STAT- MEDLINE
DCOM- 20010118
LR  - 20181130
IS  - 0022-0345 (Print)
IS  - 0022-0345 (Linking)
VI  - 79
IP  - 11
DP  - 2000 Nov
TI  - Estrogenicity of fissure sealants and adhesive resins determined by reporter gene 
      assay.
PG  - 1838-43
AB  - It is controversial whether the dental resinous materials containing 
      2,2-bis[4-(2-hydroxy-3-methacryloyloxypropoxy)phenyl]propane (Bis-GMA), which is 
      synthesized from the estrogenic compound bisphenol A (BPA), include unreacted BPA 
      and/or can mimic the effects of natural steroid hormones. In the present study, 
      the estrogenic activities of 3 fissure sealants and 5 adhesive resins, which were 
      all unpolymerized, were determined by means of a reporter gene assay, and the 
      relevance of the components to the estrogenicity was investigated. Two 
      commercially available sealants were confirmed to have estrogenic activity, 
      although none of the tested materials contained BPA. In contrast, hydrophobic 
      monomer bisphenol A dimethacrylate (BPA-DMA), which is also estrogenic, was found 
      to be included in these estrogenic sealants in an amount greater than the minimum 
      concentration to show estrogenicity. This suggests that the estrogenicity of the 
      two proprietary sealants was associated with BPA-DMA rather than with BPA.
FAU - Tarumi, H
AU  - Tarumi H
AD  - Department of Restorative Dentistry and Endodontology, Osaka University Graduate 
      School of Dentistry, Suita, Japan. tarumi@dent.osaka-u.ac.jp
FAU - Imazato, S
AU  - Imazato S
FAU - Narimatsu, M
AU  - Narimatsu M
FAU - Matsuo, M
AU  - Matsuo M
FAU - Ebisu, S
AU  - Ebisu S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Dent Res
JT  - Journal of dental research
JID - 0354343
RN  - 0 (Benzhydryl Compounds)
RN  - 0 (Composite Resins)
RN  - 0 (Estrogens, Non-Steroidal)
RN  - 0 (Methacrylates)
RN  - 0 (Phenols)
RN  - 0 (Pit and Fissure Sealants)
RN  - 0 (Polymethacrylic Acids)
RN  - 0 (Resin Cements)
RN  - 14I47YJ5EY (triethylene glycol dimethacrylate)
RN  - 3WJQ0SDW1A (Polyethylene Glycols)
RN  - 454I75YXY0 (Bisphenol A-Glycidyl Methacrylate)
RN  - 982O8255NE (2,2-di(4-methacryloxyphenyl)propane)
RN  - EC 1.13.12.- (Luciferases)
RN  - MLT3645I99 (bisphenol A)
SB  - IM
CIN - J Dent Res. 2001 Jun;80(6):1505. PMID: 11499501
MH  - Analysis of Variance
MH  - Benzhydryl Compounds
MH  - Bisphenol A-Glycidyl Methacrylate/analysis
MH  - Chromatography, High Pressure Liquid
MH  - Composite Resins/*chemistry/*toxicity
MH  - *Estrogens, Non-Steroidal/analysis
MH  - Gas Chromatography-Mass Spectrometry
MH  - Genes, Reporter
MH  - HeLa Cells/drug effects
MH  - Humans
MH  - Luciferases/genetics
MH  - Methacrylates/analysis
MH  - Phenols/analysis
MH  - Pit and Fissure Sealants/*chemistry/toxicity
MH  - Polyethylene Glycols/analysis
MH  - Polymethacrylic Acids/analysis
MH  - Resin Cements/*chemistry/toxicity
EDAT- 2001/01/06 11:00
MHDA- 2001/02/28 10:01
CRDT- 2001/01/06 11:00
PHST- 2001/01/06 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2001/01/06 11:00 [entrez]
AID - 10.1177/00220345000790110401 [doi]
PST - ppublish
SO  - J Dent Res. 2000 Nov;79(11):1838-43. doi: 10.1177/00220345000790110401.