PMID- 11146109
OWN - NLM
STAT- MEDLINE
DCOM- 20010308
LR  - 20190826
IS  - 0169-328X (Print)
IS  - 0169-328X (Linking)
VI  - 85
IP  - 1-2
DP  - 2000 Dec 28
TI  - Region- and peptide-specific regulation of the neurotrophins by estrogen.
PG  - 77-84
AB  - We have previously shown that estrogen increases the expression of brain-derived 
      neurotrophic factor (BDNF) mRNA in the olfactory bulb and cingulate cortex. Here 
      we report that estrogen regulation of BDNF protein and the structurally related 
      peptides nerve growth factor (NGF) and neurotrophin (NT)-4 is region- and 
      peptide-specific. The olfactory bulb and cingulate cortex are both 
      estrogen-sensitive targets and each receives a separate projection from neurons 
      in the horizontal limb of the diagonal band of Broca (hlDBB). Furthermore, 
      neurotrophins are retrogradely transported from the bulbar and cortical targets 
      to the hlDBB. Four weeks of estrogen replacement to ovariectomized animals 
      increased BDNF expression in the olfactory bulb, but decreased BDNF in the 
      cingulate cortex. On the other hand, estrogen increased NT-4 expression in the 
      cingulate cortex, but not in the olfactory bulb. NGF expression was not affected 
      by estrogen in either region studied. In the hlDBB, estrogen increased BDNF but 
      decreased NT-4, suggesting that estrogen differentially affects retrograde 
      accumulation of these peptides. While both estrogen receptor alpha and beta have 
      been identified in the olfactory bulb and cingulate cortex, our results indicate 
      that estrogen receptor alpha expression is relatively higher in the olfactory 
      bulb as compared to the cortex. Since the two estrogen receptors have been shown 
      to stimulate different signaling pathways, we hypothesize that estrogen acting 
      through specific receptors may differentially influence the extent and direction 
      of neurotrophin expression.
FAU - Jezierski, M K
AU  - Jezierski MK
AD  - Department of Human Anatomy and Medical Neurobiology, The Texas A&M University 
      System Health Science Center, 228 Reynolds Medical Building, College Station, 
      Texas, TX 77843-1114, USA.
FAU - Sohrabji, F
AU  - Sohrabji F
LA  - eng
GR  - NS36297/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res Mol Brain Res
JT  - Brain research. Molecular brain research
JID - 8908640
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Receptors, Estrogen)
RN  - 4TI98Z838E (Estradiol)
RN  - 9061-61-4 (Nerve Growth Factor)
RN  - P658DCA9XD (neurotrophin 4)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Cerebral Cortex/cytology/metabolism
MH  - Estradiol/*blood/pharmacology
MH  - Female
MH  - Gyrus Cinguli/cytology/metabolism
MH  - Nerve Growth Factor/metabolism
MH  - Nerve Growth Factors/*metabolism
MH  - Neurons, Afferent/chemistry/drug effects/*metabolism
MH  - Olfactory Bulb/cytology/metabolism
MH  - Ovariectomy
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Estrogen/analysis/metabolism
EDAT- 2001/01/09 11:00
MHDA- 2001/03/10 10:01
CRDT- 2001/01/09 11:00
PHST- 2001/01/09 11:00 [pubmed]
PHST- 2001/03/10 10:01 [medline]
PHST- 2001/01/09 11:00 [entrez]
AID - S0169328X00002448 [pii]
AID - 10.1016/s0169-328x(00)00244-8 [doi]
PST - ppublish
SO  - Brain Res Mol Brain Res. 2000 Dec 28;85(1-2):77-84. doi: 
      10.1016/s0169-328x(00)00244-8.