PMID- 11148147
OWN - NLM
STAT- MEDLINE
DCOM- 20020129
LR  - 20061115
IS  - 0302-4342 (Print)
IS  - 0302-4342 (Linking)
VI  - 53
IP  - 6
DP  - 2000 Dec
TI  - [Transplantation of umbilical cord blood hematopoietic progenitor cells in 
      children].
PG  - 513-9
AB  - AIM: Retrospective study of the outcome of cord blood transplantation (CBT) in 
      children in Spain. METHODS: Twenty-eight patients (mean age 6.5 years; mean 
      weight 25 kg) received a CBT between July 1994 and May 1998 in several centres of 
      the Spanish Pediatric Bone Marrow Transplant Group. In 2 patients the donor was 
      an identical human leukocyte antigen (HLA)-sibling and in two the donor was a 
      mismatched family donor. In 24 patients the donor was unrelated, and 21 of these 
      received an HLA-mismatched CBT. Twenty-one patients (75 %) received a CBT for 
      leukemia mainly in advanced phase. Seven patients were transplanted for genetic 
      disease. Of these, five had congenital immunodeficiency. The conditioning 
      treatment included total body irradiation in ten patients and combined 
      chemotherapy in the remaining patients. In all patients graft-versus-host disease 
      (GVHD) prophylaxis was performed with cyclosporine, and corticosteroids or 
      methotrexate were added in patients with HLA-mismatched donors. The mean number 
      of nucleated cells infused was 53.4 x 106/kg. RESULTS: Graft failure was observed 
      in nine patients. Eighteen patients (64.3%) developed grade IIIV acute GVHD. 
      Eight patients (28.6%) developed severe GVHD. Actuarial event free survival (EFS) 
      of all the patients was 34.4 +/- 9% at 3 years, with a mean followup of 16.6 
      months. EFS was more favorable in patients with genetic disease (71>=6 17%) and 
      in those with an HLA (A, B and DR) identical donor (6/6) (66>=6 19%). 
      CONCLUSIONS: The most favorable results were obtained in patients with genetic 
      diseases. We observed an inverse correlation between EFS and patients with HLA 
      identical donors. The high incidence of severe acute GVHD could have been related 
      to a lack of accuracy in the HLA typography of some patients.
FAU - Badell Serra I
AU  - Badell Serra I
AD  - Servicios de Pediatria, Hospital de la Santa Creu i Sant Pau, Madrid. 
      ibadell@hsp.santpau.es
FAU - Olive Oliveras T
AU  - Olive Oliveras T
FAU - Madero Lopez L
AU  - Madero Lopez L
FAU - Munoz Villa A
AU  - Munoz Villa A
FAU - Martinez Rubio A
AU  - Martinez Rubio A
FAU - Verdeguer Miralles A
AU  - Verdeguer Miralles A
FAU - Diaz De Heredia Rubio C
AU  - Diaz De Heredia Rubio C
FAU - Diaz Perez M
AU  - Diaz Perez M
FAU - Cubells Riero J
AU  - Cubells Riero J
FAU - Maldonado Regalado M
AU  - Maldonado Regalado M
FAU - Ortega Aramburu J
AU  - Ortega Aramburu J
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Trasplante de progenitores hematopoyeticos de sangre de cordon umbilical en 
      ninos.
PL  - Spain
TA  - An Esp Pediatr
JT  - Anales espanoles de pediatria
JID - 0420463
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - *Fetal Blood
MH  - Hematopoietic Stem Cell Transplantation/*statistics & numerical data
MH  - Humans
MH  - Infant
MH  - Male
MH  - Retrospective Studies
EDAT- 2001/01/10 11:00
MHDA- 2002/01/30 10:01
CRDT- 2001/01/10 11:00
PHST- 2001/01/10 11:00 [pubmed]
PHST- 2002/01/30 10:01 [medline]
PHST- 2001/01/10 11:00 [entrez]
PST - ppublish
SO  - An Esp Pediatr. 2000 Dec;53(6):513-9.