PMID- 11148715
OWN - NLM
STAT- MEDLINE
DCOM- 20010222
LR  - 20190915
IS  - 1040-8711 (Print)
IS  - 1040-8711 (Linking)
VI  - 13
IP  - 1
DP  - 2001 Jan
TI  - Update on the European Vasculitis Study Group trials.
PG  - 48-55
AB  - Over the last fifteen years, collaborative vasculitis studies in Europe have 
      established the association of antineutrophil cytoplasmic antibodies (ANCA) with 
      vasculitis and defined its clinical role as a diagnostic tool. More recently, the 
      European Vasculitis Study Group has developed a consensus approach to the 
      treatment of vasculitis and has aimed to harmonize and optimize current therapy 
      by a series of multicenter randomized controlled trials. The first trial to 
      report, CYClophosphamide or AZathioprine As a REMission therapy for vasculitis 
      (CYCAZAREM), demonstrated that, for generalized vasculitis, azathioprine is as 
      effective as continued cyclophosphamide for the maintenance of remission. Other 
      trials are investigating the roles of methotrexate, plasma exchange, and pulse 
      cyclophosphamide in acute disease, and strategies to prevent relapse over the 
      longer term. Parallel studies are determining prognostic markers, evaluating 
      tools for monitoring disease, and examining the association of ANCA and infection 
      with relapse. The established infrastructure and accumulated database are well 
      placed to facilitate testing of newer therapeutic strategies in the future.
FAU - Jayne, D
AU  - Jayne D
AD  - Senior Lecturer in Renal Medicine, Renal Unit, St. Helier Hospital, Carshalton, 
      Surrey, UK. djayne@sghms.ac.uk
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Opin Rheumatol
JT  - Current opinion in rheumatology
JID - 9000851
SB  - IM
MH  - Clinical Trials as Topic/*statistics & numerical data
MH  - Europe
MH  - Humans
MH  - Multicenter Studies as Topic/*statistics & numerical data
MH  - Vasculitis/*drug therapy
RF  - 69
EDAT- 2001/01/10 11:00
MHDA- 2001/03/03 10:01
CRDT- 2001/01/10 11:00
PHST- 2001/01/10 11:00 [pubmed]
PHST- 2001/03/03 10:01 [medline]
PHST- 2001/01/10 11:00 [entrez]
AID - 10.1097/00002281-200101000-00008 [doi]
PST - ppublish
SO  - Curr Opin Rheumatol. 2001 Jan;13(1):48-55. doi: 10.1097/00002281-200101000-00008.