PMID- 11149620
OWN - NLM
STAT- MEDLINE
DCOM- 20010222
LR  - 20220409
IS  - 0009-9163 (Print)
IS  - 0009-9163 (Linking)
VI  - 58
IP  - 6
DP  - 2000 Dec
TI  - Segregation of a supernumerary del(15) marker chromosome in sperm.
PG  - 488-92
AB  - Supernumerary marker chromosomes (SMC) can be associated with both normal and 
      abnormal phenotypes. In addition, SMC are found at higher frequency in males with 
      infertility. We identified a SMC, characterized as a del(15)(q11.2) chromosome, 
      in a phenotypically normal male. Using fluorescence in situ hybridization (FISH), 
      we examined the segregation of the del(15) chromosome in sperm from this patient. 
      Only 6.23% of sperm nuclei showed disomy using a chromosome 15 alpha-satellite 
      FISH probe, instead of the expected 50%. In addition, FISH analysis showed no 
      increase for non-disjunction of chromosome 18, excluding an interchromosomal 
      effect for this chromosome. The significant decrease in sperm bearing the del(15) 
      may be due to tissue-specific mosaicism or a result of some form of selection 
      against the del(15) during spermatogenesis. This finding provides a basis for the 
      observation that SMC(15) are less likely to be inherited from a paternal carrier.
FAU - Cotter, P D
AU  - Cotter PD
AD  - Division of Medical Genetics, Children's Hospital Oakland, CA 94609, USA. 
      pcotter@itsa.ucsf.edu
FAU - Ko, E
AU  - Ko E
FAU - Larabell, S K
AU  - Larabell SK
FAU - Rademaker, A W
AU  - Rademaker AW
FAU - Martin, R H
AU  - Martin RH
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Denmark
TA  - Clin Genet
JT  - Clinical genetics
JID - 0253664
RN  - 0 (Genetic Markers)
SB  - IM
MH  - Adult
MH  - *Chromosome Aberrations
MH  - *Chromosomes, Human, Pair 15
MH  - Cytogenetic Analysis
MH  - *Genetic Markers
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Spermatozoa/*ultrastructure
EDAT- 2001/01/10 11:00
MHDA- 2001/03/03 10:01
CRDT- 2001/01/10 11:00
PHST- 2001/01/10 11:00 [pubmed]
PHST- 2001/03/03 10:01 [medline]
PHST- 2001/01/10 11:00 [entrez]
AID - 10.1034/j.1399-0004.2000.580611.x [doi]
PST - ppublish
SO  - Clin Genet. 2000 Dec;58(6):488-92. doi: 10.1034/j.1399-0004.2000.580611.x.