PMID- 11150598
OWN - NLM
STAT- MEDLINE
DCOM- 20010118
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 123
IP  - 2
DP  - 2000 Dec
TI  - Detection of t(14; 18)(q32;q21) in hyperdiploid cells by fluorescence in situ 
      hybridization in a patient with Hodgkin disease.
PG  - 97-101
AB  - The most frequent nonrandom chromosome rearrangements in B-cell non-Hodgkin 
      lymphoma (NHL) is the t(14;18)(q32;q21) found in follicular lymphomas. The 
      t(14;18) in Hodgkin disease (HD) was rarely observed using cytogenetic 
      techniques. Although Southern blot analysis failed to demonstrate the t(14;18), 
      there have been conflicting reports concerning the occurrence of the 
      translocation using polymerase chain reaction (PCR) methods in HD. In some HD 
      tissues, the translocation might be derived from background lymphocytes rather 
      than Hodgkin and Reed-Sternberg (HRS) cells, because B-cells with t(14;18) are 
      regularly generated in normal individuals. However, the cells bearing the 
      translocation have remained unidentified. We describe a patient with HD who 
      showed t(14;18) in hyperdiploid cells using fluorescence in situ hybridization 
      (FISH) and HRS cells which were strongly positive for BCL2 by 
      immunohistochemistry. These findings suggest that HRS cells may have a t(14;18).
FAU - Miura, I
AU  - Miura I
AD  - Third Department of Internal Medicine, Akita University School of Medicine, 
      Hondo, Japan. ikuo@med.akita-u.ac.jp
FAU - Tamura, A
AU  - Tamura A
FAU - Taniwaki, M
AU  - Taniwaki M
FAU - Nakamura, S
AU  - Nakamura S
FAU - Nakamine, H
AU  - Nakamine H
FAU - Yoshino, T
AU  - Yoshino T
FAU - Ichinohasama, R
AU  - Ichinohasama R
FAU - Miura, A B
AU  - Miura AB
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (Proto-Oncogene Proteins c-bcl-2)
SB  - IM
MH  - Adult
MH  - Aneuploidy
MH  - Chromosomes, Human, Pair 14/*genetics
MH  - Chromosomes, Human, Pair 18/*genetics
MH  - Hodgkin Disease/*genetics/metabolism/pathology
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Proto-Oncogene Proteins c-bcl-2/analysis
MH  - *Translocation, Genetic
EDAT- 2001/01/11 11:00
MHDA- 2001/02/28 10:01
CRDT- 2001/01/11 11:00
PHST- 2001/01/11 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2001/01/11 11:00 [entrez]
AID - S0165-4608(00)00311-3 [pii]
AID - 10.1016/s0165-4608(00)00311-3 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2000 Dec;123(2):97-101. doi: 
      10.1016/s0165-4608(00)00311-3.