PMID- 11150605
OWN - NLM
STAT- MEDLINE
DCOM- 20010118
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 123
IP  - 2
DP  - 2000 Dec
TI  - Typical CBFbeta/MYH11 fusion due to insertion of the 3'-MYH11 gene into 16q22 in 
      acute monocytic leukemia with normal chromosomes 16 and trisomies 8 and 22.
PG  - 137-9
AB  - In a case of acute monocytic leukemia, M5a according to the FAB classification, 
      with a 48,XY,+8,+22 karyotype, amplification of the CBFbeta/MYH11 fusion 
      transcript type A was detected by reverse transcriptase-polymerase chain reaction 
      (RT-PCR). Fluorescence in situ hybridization (FISH) using an appropriate panel of 
      DNA probes showed that insertion of the 3'-MYH11 within the CBFbeta gene on 
      chromosome 16q22 was the mechanism producing the same molecular rearrangement as 
      in typical inv(16)(p13q22)/t(16;16)(p13;q22).
FAU - Aventin, A
AU  - Aventin A
AD  - Department of Hematology, University Hospital Sant Pau, Barcelona, Spain. 
      aaventin@hsp.santpau.es
FAU - La Starza, R
AU  - La Starza R
FAU - Nomdedeu, J
AU  - Nomdedeu J
FAU - Brunet, S
AU  - Brunet S
FAU - Sierra, J
AU  - Sierra J
FAU - Mecucci, C
AU  - Mecucci C
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (CBFbeta-MYH11 fusion protein)
RN  - 0 (Oncogene Proteins, Fusion)
SB  - IM
MH  - Adult
MH  - Chromosomes, Human, Pair 16/*genetics
MH  - Chromosomes, Human, Pair 22/*genetics
MH  - Chromosomes, Human, Pair 8/*genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Leukemia, Monocytic, Acute/*genetics/pathology
MH  - Male
MH  - Oncogene Proteins, Fusion/*genetics
MH  - *Trisomy
EDAT- 2001/01/11 11:00
MHDA- 2001/02/28 10:01
CRDT- 2001/01/11 11:00
PHST- 2001/01/11 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2001/01/11 11:00 [entrez]
AID - S0165-4608(00)00321-6 [pii]
AID - 10.1016/s0165-4608(00)00321-6 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2000 Dec;123(2):137-9. doi: 
      10.1016/s0165-4608(00)00321-6.