PMID- 11150921
OWN - NLM
STAT- MEDLINE
DCOM- 20010215
LR  - 20171101
IS  - 0031-7012 (Print)
IS  - 0031-7012 (Linking)
VI  - 62
IP  - 1
DP  - 2001 Jan
TI  - Reversal of Haemorrhagic Shock in Rats by Tetrahydroaminoacridine.
PG  - 36-44
AB  - The cardiovascular effects of tetrahydroaminoacridine (tacrine; THA) were 
      investigated in haemorrhaged rats. Intracerebroventricular (i.c.v.) injection of 
      THA (10, 25 and 50 microg) restored blood pressure in a dose- and time-dependent 
      manner. Atropine (10 microg, i.c.v.), a muscarinic receptor antagonist, 
      attenuated the pressor response to THA (25 microg, i.c.v.), while mecamylamine 
      (50 microg, i.c.v.), a nicotinic receptor antagonist, caused only a slight 
      blockade in the pressor effect of THA. Simultaneous pretreatment with atropine 
      and mecamylamine almost abolished the blood pressure effect of i.c.v. THA (25 
      microg). Haemorrhage increased plasma levels of adrenaline, noradrenaline, 
      vasopressin and plasma renin activity. THA (25 microg, i.c.v.) administration 
      caused additional increases in vasopressin and adrenaline levels but not of renin 
      activity and noradrenaline levels. The reversal of hypotension by THA was greatly 
      attenuated by administration of either prazosin, an alpha(1)-adrenoceptor 
      antagonist (0.5 mg/kg, i.v.) or by the vasopressin V(1) receptor antagonist 
      [beta-mercapto-beta,beta-cyclopenta-methylenepropionyl(1), 
      O-Me-Tyr(2)-Arg(8)]-vasopressin (10 microg/kg, i.v.). Pretreatment of rats with 
      both prazosin and the vasopressin antagonist simultaneously completely inhibited 
      the pressor response. Intravenous administration of THA (1, 1.5 and 3 mg/kg) also 
      reversed hypotension in rats. Atropine (10 microg, i.c.v.) greatly attenuated the 
      pressor response to THA (1.5 mg/kg, i.v.), while mecamylamine (50 microg, i.c.v.) 
      failed to change the pressor effect of THA. In anaesthetised haemorrhaged rats, 
      THA (1.5 mg/kg, i.v.) increased blood pressure and survival time of the animals. 
      These results show that centrally and peripherally injected THA reverses 
      haemorrhagic hypotension and increases survival time in rats. Activation of 
      central muscarinic and nicotinic receptors is involved in the pressor response to 
      i.c.v. THA. The pressor effect of i.v. THA is solely mediated by central 
      muscarinic receptors. Moreover, the increase in plasma adrenaline and vasopressin 
      levels appears to be involved in the pressor effect of THA.
CI  - Copyright 2001 S. Karger AG, Basel
FAU - Savci, V
AU  - Savci V
AD  - Department of Pharmacology and Clinical Pharmacology, Uludag University Medical 
      Faculty, Gorukle, Bursa, Turkey. vsavci@uludag.edu.tr
FAU - Cavun, S
AU  - Cavun S
FAU - Gurun, M S
AU  - Gurun MS
FAU - Ulus, I H
AU  - Ulus IH
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Pharmacology
JT  - Pharmacology
JID - 0152016
RN  - 0 (Adrenergic alpha-Antagonists)
RN  - 0 (Anesthetics, Intravenous)
RN  - 0 (Antidiuretic Hormone Receptor Antagonists)
RN  - 0 (Cardiovascular Agents)
RN  - 0 (Cholinesterase Inhibitors)
RN  - 11000-17-2 (Vasopressins)
RN  - 3IN71E75Z5 (Urethane)
RN  - 4VX7YNB537 (Tacrine)
RN  - 6EE945D3OK (Mecamylamine)
RN  - 7C0697DR9I (Atropine)
RN  - EC 3.4.23.15 (Renin)
RN  - X4W3ENH1CV (Norepinephrine)
RN  - XM03YJ541D (Prazosin)
RN  - YKH834O4BH (Epinephrine)
SB  - IM
MH  - Adrenergic alpha-Antagonists/pharmacology
MH  - Anesthetics, Intravenous/pharmacology
MH  - Animals
MH  - Antidiuretic Hormone Receptor Antagonists
MH  - Atropine/pharmacology
MH  - Blood Pressure/drug effects
MH  - Cardiovascular Agents/pharmacology
MH  - Cholinesterase Inhibitors/*pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Epinephrine/blood
MH  - Female
MH  - Hypotension/prevention & control
MH  - Injections, Intravenous
MH  - Injections, Intraventricular
MH  - Male
MH  - Mecamylamine/pharmacology
MH  - Norepinephrine/blood
MH  - Prazosin/pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Renin/blood/drug effects
MH  - Shock, Hemorrhagic/physiopathology/*prevention & control
MH  - Survival Analysis
MH  - Tacrine/*pharmacology
MH  - Time Factors
MH  - Urethane/pharmacology
MH  - Vasopressins/blood/drug effects
EDAT- 2001/01/11 11:00
MHDA- 2001/03/03 10:01
CRDT- 2001/01/11 11:00
PHST- 2001/01/11 11:00 [pubmed]
PHST- 2001/03/03 10:01 [medline]
PHST- 2001/01/11 11:00 [entrez]
AID - 56070 [pii]
AID - 10.1159/000056070 [doi]
PST - ppublish
SO  - Pharmacology. 2001 Jan;62(1):36-44. doi: 10.1159/000056070.