PMID- 11151652
OWN - NLM
STAT- MEDLINE
DCOM- 20010329
LR  - 20171116
IS  - 0028-2162 (Print)
IS  - 0028-2162 (Linking)
VI  - 144
IP  - 51
DP  - 2000 Dec 16
TI  - [Multiple endocrine neoplasia type 1: recent developments and guidelines for DNA 
      diagnosis and periodic clinical monitoring].
PG  - 2445-9
AB  - Multiple endocrine neoplasia type 1 (MEN-1) is an autosomal dominantly inherited 
      disorder, characterised by the occurrence of multiple tumours, particularly in 
      the parathyroid glands, the pancreatic islets, the pituitary gland, the adrenal 
      glands, as well as neuroendocrine carcinoid tumours. Since the identification of 
      the responsible gene in 1997, the diagnosis MEN-1 can be assessed easily, and 
      even presymptomatically, by DNA analysis. An early diagnosis is of importance 
      because through periodic clinical monitoring of (putative) MEN1 gene germline 
      mutation carriers, tumour development can be detected and treated at an early 
      stage. Eligible for DNA analysis are MEN-1 patients and their family members, as 
      well as patients with seemingly sporadic MEN-1 related tumours in whom on 
      clinical grounds carriership of a MEN1 gene germline mutation is suspected. 
      Eligible for periodic clinical monitoring are putative and confirmed carriers of 
      a MEN1 germline mutation from the age of 5.
FAU - Dreijerink, K M
AU  - Dreijerink KM
AD  - Divisie Inwendige Geneeskunde en Dermatologie, afd. Endocrinologie, Universitair 
      Medisch Centrum, Postbus 85.500, 3508 GA Utrecht.
FAU - Roijers, J F
AU  - Roijers JF
FAU - van der Luijt, R B
AU  - van der Luijt RB
FAU - Hoppener, J W
AU  - Hoppener JW
FAU - Lips, C J
AU  - Lips CJ
LA  - dut
PT  - Comment
PT  - Journal Article
PT  - Review
TT  - Multipele endocriene neoplasie type 1: recente ontwikkelingen en richtlijnen voor 
      DNA-diagnostiek en periodiek klinisch onderzoek.
PL  - Netherlands
TA  - Ned Tijdschr Geneeskd
JT  - Nederlands tijdschrift voor geneeskunde
JID - 0400770
SB  - IM
CON - Ned Tijdschr Geneeskd. 2000 Dec 16;144(51):2437-42. PMID: 11151650
MH  - Adult
MH  - Child
MH  - DNA Mutational Analysis/*methods
MH  - Diagnosis, Differential
MH  - Genetic Carrier Screening/methods
MH  - Genetic Testing/methods
MH  - Germ-Line Mutation/*genetics
MH  - Humans
MH  - Multiple Endocrine Neoplasia Type 1/*diagnosis/*genetics
MH  - Neoplasms, Multiple Primary/*diagnosis/genetics
MH  - Netherlands
MH  - Patient Selection
MH  - Practice Guidelines as Topic
RF  - 22
EDAT- 2001/01/11 11:00
MHDA- 2001/04/03 10:01
CRDT- 2001/01/11 11:00
PHST- 2001/01/11 11:00 [pubmed]
PHST- 2001/04/03 10:01 [medline]
PHST- 2001/01/11 11:00 [entrez]
PST - ppublish
SO  - Ned Tijdschr Geneeskd. 2000 Dec 16;144(51):2445-9.