PMID- 11152362
OWN - NLM
STAT- MEDLINE
DCOM- 20010308
LR  - 20190513
IS  - 0148-396X (Print)
IS  - 0148-396X (Linking)
VI  - 48
IP  - 1
DP  - 2001 Jan
TI  - Influence of smoking, hypertension, and sex on the phenotypic expression of 
      familial intracranial aneurysms in siblings.
PG  - 64-8; discussion 68-9
AB  - OBJECTIVE: To investigate the effects of smoking, hypertension, and sex on the 
      phenotypic expression of familial intracranial aneurysms (FIAs). METHODS: We 
      retrospectively reviewed the case records of 806 consecutive patients undergoing 
      aneurysm surgery at our institution (1986-1995) and discovered 24 families with 
      at least two affected siblings. Prevalence rates for the smoking, hypertension, 
      and sex risk factors in these nuclear families were compared with those of 
      patients with sporadic intracranial aneurysms (SIAs) and population-based control 
      patients. RESULTS: Affected family members with FIAs exhibited prevalence rates 
      of smoking and hypertension (74% and 43%, respectively) that tended to be higher 
      than those of population-based control patients (52% [P < 0.005] and 36% [P = not 
      significant (NS)], respectively) and comparable to those of patients with SIAs 
      (64% [P = NS] and 40% [P = NS], respectively). A positive association existed 
      between FIA formation and female sex but was somewhat less strong than that 
      observed in the SIAs (59% FIAs, 71% SIAs, 50% control patients). In addition, the 
      prevalence rates of smoking, hypertension, and female sex were higher in affected 
      family members with FIAs than in their unaffected siblings (58% [P < 0.05], 28% 
      [P = 0.06], and 39% [P < 0.05], respectively). Individuals in families with 
      expressed FIAs who had high aneurysmal penetrance had a greater tendency to be 
      smokers, hypertensive, and female (74%, 59%, and 55%, respectively) than did 
      their low-penetrance counterparts (61% [P = 0.1], 27% [P < 0.05], and 45% [P = 
      NS], respectively). CONCLUSION: Together these data suggest that hypertension, 
      smoking, and female sex increase the likelihood that a member of a family with an 
      expressed FIA will have an aneurysm. These observations may prove helpful in 
      guiding the use of screening studies and encouraging education about the 
      potential risks of continued tobacco use and untreated hypertension in this 
      patient cohort.
FAU - Connolly, E S Jr
AU  - Connolly ES Jr
AD  - Department of Neurological Surgery, College of Physicians and Surgeons, Columbia 
      University, New York, New York 10032-3784, USA. esc5@columbia.edu
FAU - Choudhri, T F
AU  - Choudhri TF
FAU - Mack, W J
AU  - Mack WJ
FAU - Mocco, J
AU  - Mocco J
FAU - Spinks, T J
AU  - Spinks TJ
FAU - Slosberg, J
AU  - Slosberg J
FAU - Lin, T
AU  - Lin T
FAU - Huang, J
AU  - Huang J
FAU - Solomon, R A
AU  - Solomon RA
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Neurosurgery
JT  - Neurosurgery
JID - 7802914
SB  - IM
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - Hypertension/*complications/epidemiology
MH  - Intracranial Aneurysm/*complications/*genetics/surgery
MH  - Likelihood Functions
MH  - Male
MH  - Phenotype
MH  - Prevalence
MH  - Retrospective Studies
MH  - *Sex Characteristics
MH  - Sex Distribution
MH  - Smoking/*adverse effects/epidemiology
EDAT- 2001/01/11 11:00
MHDA- 2001/03/10 10:01
CRDT- 2001/01/11 11:00
PHST- 2001/01/11 11:00 [pubmed]
PHST- 2001/03/10 10:01 [medline]
PHST- 2001/01/11 11:00 [entrez]
AID - 10.1097/00006123-200101000-00011 [doi]
PST - ppublish
SO  - Neurosurgery. 2001 Jan;48(1):64-8; discussion 68-9. doi: 
      10.1097/00006123-200101000-00011.