PMID- 11153581
OWN - NLM
STAT- MEDLINE
DCOM- 20010322
LR  - 20190822
IS  - 0903-1936 (Print)
IS  - 0903-1936 (Linking)
VI  - 16
IP  - 5
DP  - 2000 Nov
TI  - A nationwide survey in Germany on fatal asthma and near-fatal asthma in children: 
      different entities?
PG  - 845-9
AB  - In adults fatal and near-fatal asthma have similar clinical characteristics. 
      Therefore, near-fatal asthma in adults can be used as a model for fatal asthma. A 
      nationwide study on fatal and near-fatal asthma in children <16 yrs was performed 
      in order to assess whether, as in adults, near-fatal asthma can be used as a 
      model for fatal asthma. From 1996 to 1998, all paediatric hospitals and 
      paediatric pulmonologists in Germany were asked to report cases of fatal asthma 
      and near-fatal asthma to a central survey unit (Erhebungseinheit fur seltene 
      padiatrische Erkrankungen in Deutschland (ESPED)) on a monthly basis. All reports 
      were followed by detailed questionnaires. Sixteen fatal and 45 near-fatal asthma 
      cases were analysed. Fatal asthma patients were older than near-fatal asthma 
      patients. Respiratory tract infections were frequently reported only in 
      near-fatal asthma (47 versus 0%). The proportion of cases with rapid-type onset 
      (duration of symptoms < or =1 h) was higher in fatal asthma (53 versus 14%). 
      Long-term regular treatment with short acting beta2-agonists was common in both 
      groups, but the use of concomitant inhaled corticosteroids was significantly 
      lower in fatal asthma cases. A high proportion of poor compliance was observed in 
      both groups. As fatal and near-fatal asthma differ significantly in important 
      clinical aspects, analysis of near-fatal asthma might be of limited value in 
      elucidating the causes of fatal asthma in children.
FAU - Schmitz, T
AU  - Schmitz T
AD  - Dept of Paediatrics, Heinrich Heine University, Dusseldorf, Germany.
FAU - von Kries, R
AU  - von Kries R
FAU - Wjst, M
AU  - Wjst M
FAU - Schuster, A
AU  - Schuster A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Eur Respir J
JT  - The European respiratory journal
JID - 8803460
RN  - 0 (Adrenal Cortex Hormones)
RN  - 0 (Adrenergic beta-Agonists)
SB  - IM
MH  - Administration, Inhalation
MH  - Adolescent
MH  - Adrenal Cortex Hormones/administration & dosage/therapeutic use
MH  - Adrenergic beta-Agonists/therapeutic use
MH  - Age Distribution
MH  - Asthma/epidemiology/microbiology/*mortality/*physiopathology
MH  - Child
MH  - Child, Preschool
MH  - Drug Therapy, Combination
MH  - Germany
MH  - *Health Surveys
MH  - Humans
MH  - Incidence
MH  - Infant
MH  - Patient Compliance
MH  - Respiratory Tract Infections/complications/epidemiology
MH  - Time Factors
EDAT- 2001/01/12 11:00
MHDA- 2001/03/27 10:01
CRDT- 2001/01/12 11:00
PHST- 2001/01/12 11:00 [pubmed]
PHST- 2001/03/27 10:01 [medline]
PHST- 2001/01/12 11:00 [entrez]
AID - 10.1183/09031936.00.16584500 [doi]
PST - ppublish
SO  - Eur Respir J. 2000 Nov;16(5):845-9. doi: 10.1183/09031936.00.16584500.