PMID- 11154036
OWN - NLM
STAT- MEDLINE
DCOM- 20010308
LR  - 20090804
IS  - 1120-009X (Print)
IS  - 1120-009X (Linking)
VI  - 12
IP  - 6
DP  - 2000 Dec
TI  - Evaluation of interleukin-18 production by in vitro differentiated monocytes from 
      breast cancer patients.
PG  - 516-20
AB  - Interleukin-18 (IL-18) is a multifunctional cytokine which may play an important 
      role in cancer. In previous studies it has been reported that mononuclear cells 
      from breast cancer patients were defective in cytokine production. In this report 
      we examined in vitro IL-18 release by monocytes (Mo) and differentiated monocytes 
      (Mphi) for 6 or 12 days from healthy donors (HD) and nonmetastatic breast cancer 
      (BCa) patients prior to chemo-, hormonal or radiotherapy. Our results show no 
      production of this cytokine by Mo and Mphi for 6 days in all the experimental 
      conditions. HD Mphi cultured for 12 days were responsive to lipopolysaccharides 
      only after 24 h of treatment, while significantly (p<0.05) lower amounts of IL-18 
      were produced by BCa Mphi cultures in the same experimental conditions. Since BCa 
      Mphi are defective in IL-18 production, and this cytokine elicits in vivo 
      protective antitumor effects, we hypothesize a future possibility for the use of 
      IL-18 in cancer therapy.
FAU - Merendino, R A
AU  - Merendino RA
AD  - Department of Human Pathology, University of Messina Medical School, Italy.
FAU - Gangemi, S
AU  - Gangemi S
FAU - Arena, A
AU  - Arena A
FAU - Ruello, A
AU  - Ruello A
FAU - Bene, A
AU  - Bene A
FAU - Losi, E
AU  - Losi E
FAU - Mesiti, M
AU  - Mesiti M
FAU - D'Ambrosio, F P
AU  - D'Ambrosio FP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Chemother
JT  - Journal of chemotherapy (Florence, Italy)
JID - 8907348
RN  - 0 (Interleukin-18)
SB  - IM
MH  - Aged
MH  - Breast Neoplasms/metabolism/*pathology
MH  - Cell Differentiation
MH  - Female
MH  - Humans
MH  - Interleukin-18/*biosynthesis
MH  - Middle Aged
MH  - Monocytes/*metabolism
EDAT- 2001/01/12 11:00
MHDA- 2001/03/10 10:01
CRDT- 2001/01/12 11:00
PHST- 2001/01/12 11:00 [pubmed]
PHST- 2001/03/10 10:01 [medline]
PHST- 2001/01/12 11:00 [entrez]
AID - 10.1179/joc.2000.12.6.516 [doi]
PST - ppublish
SO  - J Chemother. 2000 Dec;12(6):516-20. doi: 10.1179/joc.2000.12.6.516.