PMID- 11154952
OWN - NLM
STAT- MEDLINE
DCOM- 20010315
LR  - 20220716
IS  - 0968-5243 (Print)
IS  - 0968-5243 (Linking)
VI  - 11
IP  - 3
DP  - 2000 Dec
TI  - Muscle glycogen recovery after exercise measured by 13C-magnetic resonance 
      spectroscopy in humans: effect of nutritional solutions.
PG  - 114-21
AB  - The rate of glycogen resynthesis in human skeletal muscle after 
      glycogen-depleting exercise is known to depend on carbohydrate intake and is 
      reported to reach a plateau after an adequate amount of carbohydrate (CHO) 
      consumption. Efforts to maximize the rate of glycogen storage by changing the 
      type and form of CHO, as well as by adding proteins or lipids have yielded 
      inconsistent results. The objective of this study was to assess whether 
      isocaloric addition of proteins and arginine to a CHO diet in the first 4 h after 
      an endurance exercise would increase the rate of glycogen synthesis. The CHO 
      solution, given twice at a 2 h interval according to earlier optimized protocols, 
      contained 1.7 g CHO/kg(body weieght) The effects of this solution were compared 
      to those of an isocaloric solution containing 1.2 g CHO/kg(body weight) plus 0.5 
      g protein/kg(body weight) (including 5 g arginine). Glycogen was measured in 
      quadriceps muscle in vivo with natural abundance 13C-magnetic resonance 
      spectroscopy before exercise and twice after exercise, before and at the end of a 
      4-h period following the intake of one of the solutions. Eight subjects took part 
      in a randomized cross-over trial separated by at least 1 week. Glycogen synthesis 
      was found to be significantly increased with both regimes compared to a 
      zero-caloric placebo diet, but no significant difference in glycogen resynthesis 
      was found between the CHO-only diet and the one supplemented by proteins and 
      arginine. It is estimated that significance would have been reached for an 
      increase of 34%, while the effectively measured synthesis rates only differed by 
      5%.
FAU - Rotman, S
AU  - Rotman S
AD  - Department of Life Sciences, Nestle Research Center, Lausanne, Switzerland.
FAU - Slotboom, J
AU  - Slotboom J
FAU - Kreis, R
AU  - Kreis R
FAU - Boesch, C
AU  - Boesch C
FAU - Jequier, E
AU  - Jequier E
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - MAGMA
JT  - Magma (New York, N.Y.)
JID - 9310752
RN  - 0 (Blood Glucose)
RN  - 0 (Carbon Isotopes)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Dietary Proteins)
RN  - 0 (Insulin)
RN  - 9005-79-2 (Glycogen)
RN  - 94ZLA3W45F (Arginine)
SB  - IM
MH  - Adult
MH  - Arginine/administration & dosage
MH  - Beverages
MH  - Blood Glucose/metabolism
MH  - Carbon Isotopes
MH  - Dietary Carbohydrates/administration & dosage
MH  - Dietary Proteins/administration & dosage
MH  - Exercise/*physiology
MH  - Glycogen/biosynthesis/*metabolism
MH  - Humans
MH  - Insulin/blood
MH  - Magnetic Resonance Spectroscopy/*methods
MH  - Male
MH  - Muscle, Skeletal/*metabolism
MH  - *Nutritional Physiological Phenomena
EDAT- 2001/01/13 11:00
MHDA- 2001/03/17 10:01
CRDT- 2001/01/13 11:00
PHST- 2001/01/13 11:00 [pubmed]
PHST- 2001/03/17 10:01 [medline]
PHST- 2001/01/13 11:00 [entrez]
AID - S1352866100000946 [pii]
AID - 10.1007/BF02678474 [doi]
PST - ppublish
SO  - MAGMA. 2000 Dec;11(3):114-21. doi: 10.1007/BF02678474.