PMID- 11154996
OWN - NLM
STAT- MEDLINE
DCOM- 20010208
LR  - 20171101
IS  - 0006-8977 (Print)
IS  - 0006-8977 (Linking)
VI  - 56
IP  - 4
DP  - 2000 Oct
TI  - Estradiol modulation of central monoamine activity in female mountain spiny 
      lizards.
PG  - 175-83
AB  - Although estradiol (E2) mediates many behaviors in females, relatively little is 
      known about its role in female aggression. Previous studies in female mountain 
      spiny lizards indicated that female aggression is modulated by ovariectomy and 
      sex steroid hormone replacement and that expression of aggressive behavior is 
      accompanied by changes in serotonin activity. This study examines if E2 modulates 
      the activity of serotonin and other central monoamines. Free-living females were 
      caught and housed in the laboratory and received one of 3 treatments: sham 
      surgery (SHAM), ovariectomy plus empty implant (OVEX), or sham surgery plus a 
      long lasting E2 implant (E2-IMP). After 3 weeks of treatment, selected brain 
      areas were examined for levels of monoamines and their metabolites. Changes in 
      monoamine activity were most pronounced in the septum where levels of serotonin 
      (5-HT), 5-hydroxyindoleacetic acid (5-HIAA), and norepinephrine (NE) were higher 
      in E2-IMP females relative to SHAM, and levels of 5-HIAA were higher in OVEX 
      females relative to SHAM. Changes in dopamine (DA) activity were also found, with 
      increased DA concentration and decreased ratio of forebrain:brainstem HVA 
      concentrations in E2-IMP relative to SHAM females. These results suggest that the 
      actions of E2 on aggression might be mediated, in part, by dose-dependent effects 
      on 5-HT activity in the septum.
FAU - Woodley, S K
AU  - Woodley SK
AD  - Department of Biology, Arizona State University, Tempe, Ariz., USA. 
      SWoodley@bio.bu.edu
FAU - Matt, K S
AU  - Matt KS
FAU - Moore, M C
AU  - Moore MC
LA  - eng
GR  - MH48564/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Switzerland
TA  - Brain Behav Evol
JT  - Brain, behavior and evolution
JID - 0151620
RN  - 333DO1RDJY (Serotonin)
RN  - 4TI98Z838E (Estradiol)
RN  - 54-16-0 (Hydroxyindoleacetic Acid)
RN  - VTD58H1Z2X (Dopamine)
RN  - W980KJ009P (Corticosterone)
RN  - X4W3ENH1CV (Norepinephrine)
RN  - X77S6GMS36 (Homovanillic Acid)
SB  - IM
MH  - *Aggression/drug effects
MH  - Animals
MH  - Brain/drug effects/*metabolism
MH  - Chromatography, High Pressure Liquid
MH  - Corticosterone/metabolism
MH  - Dopamine/metabolism
MH  - Dose-Response Relationship, Drug
MH  - Estradiol/metabolism/pharmacology/*physiology
MH  - Female
MH  - Homovanillic Acid/metabolism
MH  - Hydroxyindoleacetic Acid/metabolism
MH  - Lizards/*metabolism
MH  - Norepinephrine/metabolism
MH  - Ovariectomy
MH  - Seasons
MH  - Septum of Brain/metabolism
MH  - Serotonin/blood/*metabolism
EDAT- 2001/01/13 11:00
MHDA- 2001/03/03 10:01
CRDT- 2001/01/13 11:00
PHST- 2001/01/13 11:00 [pubmed]
PHST- 2001/03/03 10:01 [medline]
PHST- 2001/01/13 11:00 [entrez]
AID - 47202 [pii]
AID - 10.1159/000047202 [doi]
PST - ppublish
SO  - Brain Behav Evol. 2000 Oct;56(4):175-83. doi: 10.1159/000047202.