PMID- 11156554
OWN - NLM
STAT- MEDLINE
DCOM- 20010524
LR  - 20181113
IS  - 0007-1188 (Print)
IS  - 0007-1188 (Linking)
VI  - 132
IP  - 1
DP  - 2001 Jan
TI  - Cardiostimulant effects of urotensin-II in human heart in vitro.
PG  - 5-9
AB  - The effects of the recently identified human peptide urotensin-II (hU-II) were 
      investigated on human cardiac muscle contractility and coronary artery tone. In 
      right atrial trabeculae from non-failing hearts, hU-II caused a 
      concentration-dependent increase in contractile force (pEC(50)=9.5+/-0.1; 
      E(max)=31.3+/-4.8% compared to 9.25 mM Ca(2+); n=9) with no change in contraction 
      duration. In right ventricular trabeculae from explanted hearts, 20 nM hU-II 
      caused a small increase in contractile force (7.8+/-1.4% compared to 9.25 mM 
      Ca(2+); n=3/6 tissues from 2 out of 4 patients). The peptide caused arrhythmic 
      contractions in 3/26 right atrial trabeculae from 3/9 patients in an experimental 
      model of arrhythmia and therefore has less potential to cause arrhythmias than 
      ET-1. hU-II (20 nM) increased tone (17.9% of the response to 90 mM KCI) in 7/7 
      tissues from 1 patient, with no response detected in 8/8 tissues from 2 patients. 
      hU-II is a potent cardiac stimulant with low efficacy.
FAU - Russell, F D
AU  - Russell FD
AD  - The National Heart Foundation and Prince Charles Hospital Foundation 
      Cardiovascular Research Centre, Department of Medicine, The Prince Charles 
      Hospital, Chermside, Queensland 4032, Australia. russell@medicine.uq.edu.au
FAU - Molenaar, P
AU  - Molenaar P
FAU - O'Brien, D M
AU  - O'Brien DM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Br J Pharmacol
JT  - British journal of pharmacology
JID - 7502536
RN  - 0 (Cardiotonic Agents)
RN  - 0 (Urotensins)
RN  - 9047-55-6 (urotensin II)
SB  - IM
MH  - Arrhythmias, Cardiac/chemically induced/physiopathology
MH  - Cardiotonic Agents/*pharmacology
MH  - Coronary Vessels/drug effects
MH  - Heart/*drug effects
MH  - Heart Atria/drug effects
MH  - Heart Ventricles/drug effects
MH  - Humans
MH  - In Vitro Techniques
MH  - Muscle Tonus/drug effects
MH  - Muscle, Smooth, Vascular/drug effects
MH  - Myocardial Contraction/drug effects
MH  - Urotensins/*pharmacology
PMC - PMC1572555
EDAT- 2001/01/13 11:00
MHDA- 2001/05/26 10:01
PMCR- 2002/01/01
CRDT- 2001/01/13 11:00
PHST- 2001/01/13 11:00 [pubmed]
PHST- 2001/05/26 10:01 [medline]
PHST- 2001/01/13 11:00 [entrez]
PHST- 2002/01/01 00:00 [pmc-release]
AID - 0703811 [pii]
AID - 10.1038/sj.bjp.0703811 [doi]
PST - ppublish
SO  - Br J Pharmacol. 2001 Jan;132(1):5-9. doi: 10.1038/sj.bjp.0703811.