PMID- 11158412
OWN - NLM
STAT- MEDLINE
DCOM- 20010329
LR  - 20190513
IS  - 0931-0509 (Print)
IS  - 0931-0509 (Linking)
VI  - 16
IP  - 2
DP  - 2001 Feb
TI  - The effect of HLA-C matching on acute renal transplant rejection.
PG  - 355-60
AB  - BACKGROUND: The acute immunological rejection and long time survival of kidney 
      allografts are correlated with the human leukocyte antigen (HLA) match status 
      between donor and recipient. HLA-A, -B and -DR have all turned out to be relevant 
      HLA loci in several studies. The role of HLA-C has not been studied before now. 
      METHODS: In 104 consecutive patient/donor pairs from our transplantation unit, we 
      retrospectively analysed whether acute graft rejection is influenced by HLA-C 
      match status between donor and recipient. For typing HLA-C alleles, we used an 
      allele-specific PCR protocol in combination with serology. RESULTS: By analysing 
      groups of donor/recipient pairs with a homogeneous distribution of HLA-B 
      mismatches in order to exclude an effect of the linkage disequilibrium between 
      HLA-B/C, HLA-C mismatch turned out to be significantly correlated with acute 
      transplant rejection in pairs with one additional mismatch on the B locus 
      (P=0.004). Additional parameters that may hypothetically influence acute 
      rejection episodes (HLA-A or DR mismatch, time of cold and warm ischaemia, 
      previous transplantations, pre-existing HLA antibodies) were also analysed but 
      cannot explain this finding. CONCLUSION: HLA-C matching of all kidney donors and 
      recipients seems to be an option to reduce the probability of acute rejection 
      episodes. Further studies of greater patient cohorts analysing organ rejection 
      and organ survival are warranted.
FAU - Frohn, C
AU  - Frohn C
AD  - Institute of Immunology and Transfusion Medicine, University of Lubeck School of 
      Medicine, Lubeck, Germany.
FAU - Fricke, L
AU  - Fricke L
FAU - Puchta, J C
AU  - Puchta JC
FAU - Kirchner, H
AU  - Kirchner H
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nephrol Dial Transplant
JT  - Nephrology, dialysis, transplantation : official publication of the European 
      Dialysis and Transplant Association - European Renal Association
JID - 8706402
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-C Antigens)
SB  - IM
MH  - Alleles
MH  - Cadaver
MH  - Genotype
MH  - Graft Rejection/*immunology
MH  - Graft Survival
MH  - HLA-B Antigens/analysis
MH  - HLA-C Antigens/*analysis/genetics
MH  - *Histocompatibility Testing
MH  - Humans
MH  - Kidney Transplantation/*immunology
MH  - Retrospective Studies
MH  - Serotyping
MH  - Survival Analysis
EDAT- 2001/02/07 11:00
MHDA- 2001/04/03 10:01
CRDT- 2001/02/07 11:00
PHST- 2001/02/07 11:00 [pubmed]
PHST- 2001/04/03 10:01 [medline]
PHST- 2001/02/07 11:00 [entrez]
AID - 10.1093/ndt/16.2.355 [doi]
PST - ppublish
SO  - Nephrol Dial Transplant. 2001 Feb;16(2):355-60. doi: 10.1093/ndt/16.2.355.