PMID- 11158724
OWN - NLM
STAT- MEDLINE
DCOM- 20010412
LR  - 20190513
IS  - 1096-6080 (Print)
IS  - 1096-0929 (Linking)
VI  - 59
IP  - 2
DP  - 2001 Feb
TI  - Pregnancy loss in the rat caused by bromodichloromethane.
PG  - 309-15
AB  - Bromodichloromethane (BDCM), a trihalomethane, is a by-product of the 
      chlorination of drinking water. In a recent epidemiological study, consumption of 
      BDCM was associated with an increased risk of spontaneous abortion in pregnant 
      women. We have previously shown that BDCM causes pregnancy loss, i.e., 
      full-litter resorption (FLR), in the F344 rat. The mode of action was 
      investigated, with three main findings. First, there was a dramatic difference in 
      sensitivity between F344 and Sprague-Dawley (SD) rat strains. Following aqueous 
      gavage treatment on gestational days (GD) 6-10, F344 rats had a 62% incidence of 
      FLR at 75 mg/kg/day, whereas all SD rats maintained their litters. Second, the 
      critical period encompassed the luteinizing hormone (LH)-dependent period of 
      pregnancy. Rats treated on GD 6-10 at 75 mg/kg/day had a 75% incidence of FLR, 
      but rats treated on GD 11-15 at 75 or 100 mg/kg/day were unaffected. Third, 24 h 
      after a single dose, all dams with FLR had markedly reduced serum progesterone 
      levels; however, LH levels were unaffected. The high FLR rate during the 
      LH-dependent period, the lack of response thereafter, and the reduced 
      progesterone levels without an associated reduction in LH levels suggests that 
      BDCM disrupts luteal responsiveness to LH.
FAU - Bielmeier, S R
AU  - Bielmeier SR
AD  - Curriculum of Toxicology, University of North Carolina at Chapel Hill, Chapel 
      Hill, North Carolina, USA. bielmeier.susan@epa.gov
FAU - Best, D S
AU  - Best DS
FAU - Guidici, D L
AU  - Guidici DL
FAU - Narotsky, M G
AU  - Narotsky MG
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Toxicol Sci
JT  - Toxicological sciences : an official journal of the Society of Toxicology
JID - 9805461
RN  - 0 (Carcinogens)
RN  - 0 (Trihalomethanes)
RN  - 4G7DS2Q64Y (Progesterone)
RN  - 7LN464CH2O (bromodichloromethane)
RN  - 9002-67-9 (Luteinizing Hormone)
SB  - IM
MH  - Animals
MH  - Body Weight/drug effects
MH  - Carcinogens/*toxicity
MH  - Dose-Response Relationship, Drug
MH  - Embryo Loss/*chemically induced
MH  - Female
MH  - Fetal Resorption/*chemically induced
MH  - Luteinizing Hormone/blood
MH  - Pregnancy
MH  - Pregnancy, Animal/blood/*drug effects
MH  - Progesterone/blood
MH  - Rats
MH  - Rats, Inbred F344
MH  - Rats, Sprague-Dawley
MH  - Species Specificity
MH  - Trihalomethanes/*toxicity
EDAT- 2001/02/07 11:00
MHDA- 2001/04/17 10:01
CRDT- 2001/02/07 11:00
PHST- 2001/02/07 11:00 [pubmed]
PHST- 2001/04/17 10:01 [medline]
PHST- 2001/02/07 11:00 [entrez]
AID - 10.1093/toxsci/59.2.309 [doi]
PST - ppublish
SO  - Toxicol Sci. 2001 Feb;59(2):309-15. doi: 10.1093/toxsci/59.2.309.