PMID- 11158965
OWN - NLM
STAT- MEDLINE
DCOM- 20010322
LR  - 20200930
IS  - 0363-6135 (Print)
IS  - 0363-6135 (Linking)
VI  - 280
IP  - 2
DP  - 2001 Feb
TI  - Involvement of iNOS in postischemic heart dysfunction of stroke-prone 
      spontaneously hypertensive rats.
PG  - H668-73
AB  - We investigated the possible contribution of inducible nitric oxide synthase 
      (iNOS) to postischemic heart dysfunction and injuries in stroke-prone 
      spontaneously hypertensive rats (SHRSP). SHRSP, 13-14 wk of age, had 
      significantly higher systolic blood pressure and greater heart weight than 
      age-matched Wistar-Kyoto rats (WKY). Permanent occlusion of the left anterior 
      descending coronary artery (LAD) caused significant and long-lasting increases in 
      the activity and mRNA expression of myocardial iNOS in SHRSP compared with WKY. 
      However, there was no significant difference in the LAD occlusion-induced 
      expression of interleukin-1beta mRNA between SHRSP and WKY. Hemodynamic 
      deterioration and myocardial fibrosis were also observed in SHRSP at 4 wk after 
      LAD occlusion. Continuous administration of 
      2-amino-5,6-dihydro-6-methyl-4H-1,2-thiazin (AMT) completely blocked the LAD 
      occlusion-induced increase in the myocardial iNOS activity of SHRSP. Moreover, 
      postischemic heart dysfunction and injuries were also significantly ameliorated 
      by 2-amino-5,6-dihydro-6-methyl-4H-1,2-thiazin (AMT). These results suggest that 
      the increased activity of myocardial iNOS plays a pivotal role in the development 
      of postischemic cardiac dysfunction and injuries in SHRSP with the hypertensive 
      and hypertrophic heart.
FAU - Abe, K
AU  - Abe K
AD  - Department of Drug Safety Evaluation, Developmental Research Laboratories, 
      Shionogi & Co., Ltd., Toyonaka, Osaka 561-0825, Japan. kohji.abe@shionogi.co.jp
FAU - Tokumura, M
AU  - Tokumura M
FAU - Ito, T
AU  - Ito T
FAU - Murai, T
AU  - Murai T
FAU - Takashima, A
AU  - Takashima A
FAU - Ibii, N
AU  - Ibii N
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Physiol Heart Circ Physiol
JT  - American journal of physiology. Heart and circulatory physiology
JID - 100901228
RN  - 0 (2-amino-5,6-dihydro-6-methyl-4H-1,3-thiazine)
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Interleukin-1)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (RNA, Messenger)
RN  - 0 (Thiazines)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase Type II)
RN  - EC 1.14.13.39 (Nos2 protein, rat)
SB  - IM
MH  - Animals
MH  - Cardiomegaly/metabolism/pathology
MH  - Coronary Circulation
MH  - Coronary Disease/metabolism/pathology
MH  - Enzyme Inhibitors/pharmacology
MH  - Fetal Blood
MH  - Gene Expression Regulation, Enzymologic/drug effects
MH  - Interleukin-1/genetics
MH  - Lipopolysaccharides/pharmacology
MH  - Male
MH  - Myocardial Ischemia/*metabolism/pathology
MH  - Myocardium/*enzymology/pathology
MH  - Nitric Oxide Synthase/antagonists & inhibitors/*genetics/*metabolism
MH  - Nitric Oxide Synthase Type II
MH  - Organ Size
MH  - RNA, Messenger/analysis
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Rats, Inbred WKY
MH  - Stroke/metabolism
MH  - Thiazines/pharmacology
EDAT- 2001/02/13 11:00
MHDA- 2001/03/27 10:01
CRDT- 2001/02/13 11:00
PHST- 2001/02/13 11:00 [pubmed]
PHST- 2001/03/27 10:01 [medline]
PHST- 2001/02/13 11:00 [entrez]
AID - 10.1152/ajpheart.2001.280.2.H668 [doi]
PST - ppublish
SO  - Am J Physiol Heart Circ Physiol. 2001 Feb;280(2):H668-73. doi: 
      10.1152/ajpheart.2001.280.2.H668.