PMID- 11160041
OWN - NLM
STAT- MEDLINE
DCOM- 20010705
LR  - 20171213
IS  - 8750-7587 (Print)
IS  - 0161-7567 (Linking)
VI  - 90
IP  - 2
DP  - 2001 Feb
TI  - Glucose kinetics and substrate oxidation during exercise in the follicular and 
      luteal phases.
PG  - 447-53
AB  - The purpose of this investigation was to determine whether plasma glucose 
      kinetics and substrate oxidation during exercise are dependent on the phase of 
      the menstrual cycle. Once during the follicular (F) and luteal (L) phases, 
      moderately trained subjects [peak O(2) uptake (V(O(2))) = 48.2 +/- 1.1 ml. 
      min(-1). kg(-1); n = 6] cycled for 25 min at approximately 70% of the V(O(2)) at 
      their respective lactate threshold (70%LT), followed immediately by 25 min at 
      90%LT. Rates of plasma glucose appearance (R(a)) and disappearance (R(d)) were 
      determined with a primed constant infusion of [6,6-(2)H]glucose, and total 
      carbohydrate (CHO) and fat oxidation were determined with indirect calorimetry. 
      At rest and during exercise at 70%LT, there were no differences in glucose R(a) 
      or R(d) between phases. CHO and fat oxidation were not different between phases 
      at 70%LT. At 90%LT, glucose R(a) (28.8 +/- 4.8 vs. 33.7 +/- 4.5 micromol. 
      min(-1). kg(-1); P < 0.05) and R(d) (28.4 +/- 4.8 vs. 34.0 +/- 4.1 micromol. 
      min(-1). kg(-1); P < 0.05) were lower during the L phase. In addition, at 90%LT, 
      CHO oxidation was lower during the L compared with the F phase (82.0 +/- 12.3 vs. 
      93.8 +/- 9.7 micromol. min(-1) .kg(-1); P < 0.05). Conversely, total fat 
      oxidation was greater during the L phase at 90%LT (7.46 +/- 1.01 vs. 6.05 +/- 
      0.89 micromol. min(-1). kg(-1); P < 0.05). Plasma lactate concentration was also 
      lower during the L phase at 90%LT concentrations (2.48 +/- 0.41 vs. 3.08 +/- 0.39 
      mmol/l; P < 0.05). The lower CHO utilization during the L phase was associated 
      with an elevated resting estradiol (P < 0.05). These results indicate that plasma 
      glucose kinetics and CHO oxidation during moderate-intensity exercise are lower 
      during the L compared with the F phase in women. These differences may have been 
      due to differences in circulating estradiol.
FAU - Zderic, T W
AU  - Zderic TW
AD  - Human Performance Laboratory, University of Montana, Missoula, Montana 
      59812-1825, USA.
FAU - Coggan, A R
AU  - Coggan AR
FAU - Ruby, B C
AU  - Ruby BC
LA  - eng
GR  - AG-14769/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Appl Physiol (1985)
JT  - Journal of applied physiology (Bethesda, Md. : 1985)
JID - 8502536
RN  - 0 (Blood Glucose)
RN  - 0 (Fats)
RN  - 0 (Insulin)
RN  - 12629-01-5 (Human Growth Hormone)
RN  - 33X04XA5AT (Lactic Acid)
RN  - 4TI98Z838E (Estradiol)
RN  - PDC6A3C0OX (Glycerol)
SB  - IM
MH  - Adult
MH  - Blood Glucose/*metabolism
MH  - *Carbohydrate Metabolism
MH  - Estradiol/blood
MH  - *Exercise
MH  - Fats/metabolism
MH  - Female
MH  - Follicular Phase/blood/*metabolism
MH  - Glycerol/blood
MH  - Human Growth Hormone/blood
MH  - Humans
MH  - Insulin/blood
MH  - Kinetics
MH  - Lactic Acid/blood
MH  - Luteal Phase/blood/*metabolism
MH  - Oxidation-Reduction
MH  - Oxygen Consumption
EDAT- 2001/02/13 11:00
MHDA- 2001/07/06 10:01
CRDT- 2001/02/13 11:00
PHST- 2001/02/13 11:00 [pubmed]
PHST- 2001/07/06 10:01 [medline]
PHST- 2001/02/13 11:00 [entrez]
AID - 10.1152/jappl.2001.90.2.447 [doi]
PST - ppublish
SO  - J Appl Physiol (1985). 2001 Feb;90(2):447-53. doi: 10.1152/jappl.2001.90.2.447.