PMID- 11161778
OWN - NLM
STAT- MEDLINE
DCOM- 20010607
LR  - 20101118
IS  - 0888-7543 (Print)
IS  - 0888-7543 (Linking)
VI  - 70
IP  - 3
DP  - 2000 Dec 15
TI  - A high-density genetic map of the chromosome 13q14 atopy locus.
PG  - 286-91
AB  - Atopy describes a syndrome of immunoglobulin E (IgE)-mediated allergy that 
      underlies asthma and infantile eczema. We have previously identified a locus on 
      chromosome 13q14 that is linked to atopy and to the total serum immunoglobulin A 
      concentration. We have therefore made a saturation genetic map of the region by 
      typing 59 polymorphic microsatellite loci on chromosome 13q. Multipoint linkage 
      analysis identified a 1-LOD support unit for the location of the atopy locus with 
      a 7.5-cM region flanked by the loci D13S328 and D13S1269. The peak of linkage was 
      at locus D13S161 with a nonparametric -log of P score of approximately 4.5. 
      Parent of origin effects were present, with linkage primarily observed to 
      paternally derived alleles. The genetic map of this region provides a basis for 
      the effective identification of the chromosome 13 atopy gene.
FAU - Bhattacharyya, S
AU  - Bhattacharyya S
AD  - Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, 
      Headington, OX3 7BN, United Kingdom.
FAU - Leaves, N I
AU  - Leaves NI
FAU - Wiltshire, S
AU  - Wiltshire S
FAU - Cox, R
AU  - Cox R
FAU - Cookson, W O
AU  - Cookson WO
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Genomics
JT  - Genomics
JID - 8800135
RN  - 0 (Immunoglobulin A)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - *Chromosome Mapping
MH  - *Chromosomes, Human, Pair 13
MH  - Female
MH  - Genetic Linkage
MH  - Humans
MH  - Hypersensitivity/*genetics
MH  - Immunoglobulin A/blood
MH  - Male
MH  - Middle Aged
EDAT- 2001/02/13 11:00
MHDA- 2001/06/08 10:01
CRDT- 2001/02/13 11:00
PHST- 2001/02/13 11:00 [pubmed]
PHST- 2001/06/08 10:01 [medline]
PHST- 2001/02/13 11:00 [entrez]
AID - S0888-7543(00)96398-5 [pii]
AID - 10.1006/geno.2000.6398 [doi]
PST - ppublish
SO  - Genomics. 2000 Dec 15;70(3):286-91. doi: 10.1006/geno.2000.6398.