PMID- 11163081
OWN - NLM
STAT- MEDLINE
DCOM- 20010607
LR  - 20190906
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 61
IP  - 12
DP  - 2000 Dec
TI  - Tumor necrosis factor, tumor necrosis factor receptors type 1 and 2, 
      lymphotoxin-alpha, and HLA-DRB1 gene polymorphisms in human T-cell lymphotropic 
      virus type I associated myelopathy.
PG  - 1262-9
AB  - We studied tumor necrosis factor (TNF), lymphotoxin-alpha (LT-alpha), and TNF 
      receptors type 1 (TNFR-1) and type 2 (TNFR-2) gene polymorphisms as well as HLA 
      class II DRB1 alleles in Japanese patients with human T-cell lymphotropic virus 
      type I (HTLV-I) associated myelopathy (HAM) (n = 51), patients with adult T-cell 
      leukemia/lymphoma (ATL) (n = 48), asymptomatic HTLV-I carriers (n = 50), and 
      HTLV-I seronegative, normal controls (n = 112). There were significant 
      differences between HAM patients and normal controls in the distributions of TNF 
      promoter region polymophism at position --857, the LT-alpha gene NcoI 
      polymorphism, and the T-G substitution in exon 6 of the TNFR-2 gene. The 
      distribution of the NcoI polymorphism of the LT-alpha gene was also significantly 
      different between HAM patients and asymptomatic HTLV-I carriers. In contrast, we 
      failed to detect any difference in the frequency of DRB1, TNF promoter at 
      position --1031, --863, or the TNFR-1 promoter --383 polymorphism. The results 
      suggest that the TNF/LT-alpha gene region within the HLA class III of chromosome 
      6 and the TNFR-2 gene region located on chromosome 1p36 might contribute to 
      susceptibility to HAM, and that aberrant expression or function of these 
      cytokines and the receptor could be involved in the development of HAM.
FAU - Nishimura, M
AU  - Nishimura M
AD  - Department of Neurology and Clinical Research Center, Utano National Hospital, 
      Kyoto, Japan.
FAU - Maeda, M
AU  - Maeda M
FAU - Matsuoka, M
AU  - Matsuoka M
FAU - Mine, H
AU  - Mine H
FAU - Saji, H
AU  - Saji H
FAU - Matsui, M
AU  - Matsui M
FAU - Kuroda, Y
AU  - Kuroda Y
FAU - Kawakami, H
AU  - Kawakami H
FAU - Uchiyama, T
AU  - Uchiyama T
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Antigens, CD)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (Lymphotoxin-alpha)
RN  - 0 (Receptors, Tumor Necrosis Factor)
RN  - 0 (Receptors, Tumor Necrosis Factor, Type I)
RN  - 0 (Receptors, Tumor Necrosis Factor, Type II)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - EC 3.1.21.- (endodeoxyribonuclease NcoI)
RN  - EC 3.1.21.4 (Deoxyribonucleases, Type II Site-Specific)
SB  - IM
MH  - Alleles
MH  - Antigens, CD/*genetics
MH  - Carrier State/immunology/virology
MH  - Deoxyribonucleases, Type II Site-Specific/genetics
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Leukemia-Lymphoma, Adult T-Cell/genetics/immunology
MH  - Linkage Disequilibrium/immunology
MH  - Lymphotoxin-alpha/*genetics
MH  - Microsatellite Repeats
MH  - Paraparesis, Tropical Spastic/*genetics/*immunology
MH  - *Polymorphism, Restriction Fragment Length
MH  - Promoter Regions, Genetic/immunology
MH  - Receptors, Tumor Necrosis Factor/*genetics
MH  - Receptors, Tumor Necrosis Factor, Type I
MH  - Receptors, Tumor Necrosis Factor, Type II
MH  - Tumor Necrosis Factor-alpha/*genetics
EDAT- 2001/02/13 11:00
MHDA- 2001/06/08 10:01
CRDT- 2001/02/13 11:00
PHST- 2001/02/13 11:00 [pubmed]
PHST- 2001/06/08 10:01 [medline]
PHST- 2001/02/13 11:00 [entrez]
AID - S0198885900001828 [pii]
AID - 10.1016/s0198-8859(00)00182-8 [doi]
PST - ppublish
SO  - Hum Immunol. 2000 Dec;61(12):1262-9. doi: 10.1016/s0198-8859(00)00182-8.