PMID- 11163102
OWN - NLM
STAT- MEDLINE
DCOM- 20010308
LR  - 20190720
IS  - 0304-3835 (Print)
IS  - 0304-3835 (Linking)
VI  - 163
IP  - 1
DP  - 2001 Feb 10
TI  - Cancer chemopreventive activity of 3,5,6,7,8,3',4'-heptamethoxyflavone from the 
      peel of citrus plants.
PG  - 7-9
AB  - Nobiletin and 3,5,6,7,8,3',4'-heptamethoxyflavone (HPT), isolated from the peel 
      of Citrus plants, were examined for the anti-tumor-initiating activity on 
      two-stage carcinogenesis of mouse skin tumors induced by a nitric oxide donor, 
      (+/-)-(E)-methyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexenamide, as an 
      initiator and 12-O-tetradecanoylphorbol-13-acetate as a promoter. HPT exhibited 
      the remarkable anti-tumor-initiating effect on mouse skin and it suggested the 
      possibility of HPT being a chemopreventive agent against nitric oxide (NO) 
      carcinogenesis.
FAU - Iwase, Y
AU  - Iwase Y
AD  - Faculty of Pharmaceutical Sciences, Mukogawa Women's University, 11-68 Koshien 
      Kyubancho, Nishinomiya, 663-8179, Hyogo, Japan.
FAU - Takemura, Y
AU  - Takemura Y
FAU - Ju-ichi, M
AU  - Ju-ichi M
FAU - Yano, M
AU  - Yano M
FAU - Ito, C
AU  - Ito C
FAU - Furukawa, H
AU  - Furukawa H
FAU - Mukainaka, T
AU  - Mukainaka T
FAU - Kuchide, M
AU  - Kuchide M
FAU - Tokuda, H
AU  - Tokuda H
FAU - Nishino, H
AU  - Nishino H
LA  - eng
PT  - Journal Article
PL  - Ireland
TA  - Cancer Lett
JT  - Cancer letters
JID - 7600053
RN  - 0 (Anticarcinogenic Agents)
RN  - 0 (Carcinogens)
RN  - 0 (Flavones)
RN  - 0 (Flavonoids)
RN  - 0 (Nitro Compounds)
RN  - 0 (Plant Extracts)
RN  - 0 (methyl-2-hydroxyimino-5-nitro-6-methoxy-3-hexeneamide)
RN  - 1178-24-1 (3,3',4',5,6,7,8-heptamethoxyflavone)
RN  - 57-97-6 (9,10-Dimethyl-1,2-benzanthracene)
RN  - D65ILJ7WLY (nobiletin)
RN  - NI40JAQ945 (Tetradecanoylphorbol Acetate)
SB  - IM
MH  - 9,10-Dimethyl-1,2-benzanthracene/administration & dosage
MH  - Animals
MH  - Anticarcinogenic Agents/pharmacology
MH  - Carcinogens/administration & dosage
MH  - Citrus/*chemistry
MH  - Female
MH  - *Flavones
MH  - Flavonoids/*pharmacology
MH  - Mice
MH  - Nitro Compounds/administration & dosage
MH  - Papilloma/chemically induced/prevention & control
MH  - Plant Extracts/chemistry/pharmacology
MH  - Skin Neoplasms/chemically induced/*prevention & control
MH  - Specific Pathogen-Free Organisms
MH  - Tetradecanoylphorbol Acetate/adverse effects
MH  - Time Factors
EDAT- 2001/02/13 11:00
MHDA- 2001/03/10 10:01
CRDT- 2001/02/13 11:00
PHST- 2001/02/13 11:00 [pubmed]
PHST- 2001/03/10 10:01 [medline]
PHST- 2001/02/13 11:00 [entrez]
AID - S0304383500006911 [pii]
AID - 10.1016/s0304-3835(00)00691-1 [doi]
PST - ppublish
SO  - Cancer Lett. 2001 Feb 10;163(1):7-9. doi: 10.1016/s0304-3835(00)00691-1.