PMID- 11163860 OWN - NLM STAT- MEDLINE DCOM- 20010621 LR - 20190826 IS - 0165-2478 (Print) IS - 0165-2478 (Linking) VI - 75 IP - 1 DP - 2000 Dec 1 TI - Proinflammatory and antitumor properties of interleukin-18 in the gastrointestinal tract. PG - 9-14 AB - Interleukin-18 (IL-18) plays a central role in the immune response by acting on Th1 cell differentiation, cell-mediated cytotoxicity and inflammation. The role of IL-18 in cancers and inflammatory diseases is discussed in the light of our investigations on IL-18 synthesis in normal colonic mucosa, colonic cancer and Crohn's disease (CD). FAU - Pages, F AU - Pages F AD - Laboratoire Universitaire de Transfert en Immunologie, Universites Paris V, Paris VI/Laboratorie Pierre Fabre, France. frank.pages@cochin.univ-paris5.fr FAU - Berger, A AU - Berger A FAU - Lebel-Binay, S AU - Lebel-Binay S FAU - Zinzindohoue, F AU - Zinzindohoue F FAU - Danel, C AU - Danel C FAU - Piqueras, B AU - Piqueras B FAU - Carriere, O AU - Carriere O FAU - Thiounn, N AU - Thiounn N FAU - Cugnenc, P H AU - Cugnenc PH FAU - Fridman, W H AU - Fridman WH LA - eng PT - Journal Article PT - Review PL - Netherlands TA - Immunol Lett JT - Immunology letters JID - 7910006 RN - 0 (Interleukin-18) SB - IM MH - Colonic Neoplasms/*immunology/pathology MH - Crohn Disease/*immunology/pathology MH - Humans MH - *Inflammation/immunology/physiopathology MH - Interleukin-18/*biosynthesis/chemistry/*physiology MH - Intestinal Mucosa/*immunology/metabolism RF - 44 EDAT- 2001/02/13 11:00 MHDA- 2001/06/22 10:01 CRDT- 2001/02/13 11:00 PHST- 2001/02/13 11:00 [pubmed] PHST- 2001/06/22 10:01 [medline] PHST- 2001/02/13 11:00 [entrez] AID - S0165-2478(00)00285-6 [pii] AID - 10.1016/s0165-2478(00)00285-6 [doi] PST - ppublish SO - Immunol Lett. 2000 Dec 1;75(1):9-14. doi: 10.1016/s0165-2478(00)00285-6.