PMID- 11164260
OWN - NLM
STAT- MEDLINE
DCOM- 20010503
LR  - 20190915
IS  - 0168-0102 (Print)
IS  - 0168-0102 (Linking)
VI  - 39
IP  - 1
DP  - 2001 Jan
TI  - Unmasking of silent "task-related" neuronal activity in the monkey prefrontal 
      cortex by a GABA(A) antagonist.
PG  - 123-31
AB  - To examine the role of GABA on prefrontal neuronal activity in the control of 
      behavior, a GABA(A) receptor antagonist, bicuculline methiodite (BMI), was 
      iontophoretically applied to prefrontal neurons while monkeys performed a visual 
      reaction time task. Iontophoretic application of BMI uncovered "task-related" 
      activity of silent neurons (n=40), which did not show any activity during 
      performance of the task. The distribution, by type, of these silent 
      "task-related" neurons differed from that of standard (i.e. active) task-related 
      neurons (N=95), and a particular type of silent "task-related" neuron was found 
      most frequently. These findings suggest that GABA continuously and preferentially 
      suppresses neuronal activity via GABA(A) receptors to limit the population of 
      prefrontal neurons related to behavior, thereby organizing neuronal activities 
      for behavior mediated by the prefrontal cortex.
FAU - Sawaguchi, T
AU  - Sawaguchi T
AD  - Department of Behavioral and Brain Sciences, Primate Research Institute, Kyoto 
      University, Inuyama, Aichi 484-8506, Japan. toshi-sw@med.hokudai.ac.jp
LA  - eng
PT  - Journal Article
PL  - Ireland
TA  - Neurosci Res
JT  - Neuroscience research
JID - 8500749
RN  - 0 (GABA-A Receptor Antagonists)
RN  - 40709-69-1 (bicuculline methiodide)
RN  - 56-12-2 (gamma-Aminobutyric Acid)
RN  - Y37615DVKC (Bicuculline)
SB  - IM
MH  - Animals
MH  - Bicuculline/*analogs & derivatives/*pharmacology
MH  - *GABA-A Receptor Antagonists
MH  - Macaca mulatta
MH  - Male
MH  - Neurons/*drug effects/physiology
MH  - Prefrontal Cortex/*drug effects/physiology
MH  - Psychomotor Performance/*drug effects/physiology
MH  - Reaction Time/*drug effects/physiology
MH  - gamma-Aminobutyric Acid/*pharmacology
EDAT- 2001/02/13 11:00
MHDA- 2001/05/05 10:01
CRDT- 2001/02/13 11:00
PHST- 2001/02/13 11:00 [pubmed]
PHST- 2001/05/05 10:01 [medline]
PHST- 2001/02/13 11:00 [entrez]
AID - S0168-0102(00)00204-2 [pii]
AID - 10.1016/s0168-0102(00)00204-2 [doi]
PST - ppublish
SO  - Neurosci Res. 2001 Jan;39(1):123-31. doi: 10.1016/s0168-0102(00)00204-2.