PMID- 11164827
OWN - NLM
STAT- MEDLINE
DCOM- 20010510
LR  - 20220331
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 891
IP  - 1-2
DP  - 2001 Feb 9
TI  - Differential expression of GDNF, BDNF, and NT-3 in the aging nigrostriatal system 
      following a neurotoxic lesion.
PG  - 228-35
AB  - Protein levels for brain-derived neurotrophic factor (BDNF), neurotrophin-3 
      (NT-3), and glial cell line-derived neurotrophic factor (GDNF) were measured in 
      the striatum and ventral midbrain of young and aged Brown Norway/F344 F1 
      (F344BNF(1)) hybrid rats following a unilateral 6-hydroxydopamine (6-OHDA) lesion 
      of the nigrostriatal pathway. At 2 weeks post-lesion, protein levels of BDNF and 
      GDNF were higher in the denervated striatum when compared to the intact striatum 
      for young (4-5 months old) but not old (31-33 months old) rats. Interestingly, in 
      old rats BDNF protein in the denervated striatum was significantly lower than 
      that measured in the intact striatum. At the same time point BDNF protein levels 
      in the ventral midbrain were higher on the lesioned versus intact side for both 
      young and old rats while no significant side differences were detected for GDNF 
      protein in the ventral midbrain of young or old rats. No significant differences 
      in NT-3 protein levels were detected between the lesioned and intact sides for 
      striatal or ventral midbrain regions in either young or old brain. While no 
      significant age effects were detected for BDNF or NT-3 protein, young rats showed 
      higher GDNF protein levels in both the striatum (lesioned or intact) and ventral 
      midbrain (lesioned or intact) than old rats. These data show that two endogenous 
      neurotrophic factors, BDNF and GDNF, are differentially affected by a 6-OHDA 
      lesion in the aging nigrostriatal system with young brain showing a significant 
      compensatory increase of these two factors in the denervated striatum while no 
      compensatory increase is observed in aged brain.
FAU - Yurek, D M
AU  - Yurek DM
AD  - Department of Surgery/Neurosurgery, University of Kentucky College of Medicine, 
      Health Sciences Research Building, Lexington, Kentucky, KY 40536-0305, USA. 
      dyure00@pop.uky.edu
FAU - Fletcher-Turner, A
AU  - Fletcher-Turner A
LA  - eng
GR  - NS35890/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Gdnf protein, rat)
RN  - 0 (Glial Cell Line-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Neurotoxins)
RN  - 0 (Neurotrophin 3)
RN  - 8HW4YBZ748 (Oxidopamine)
SB  - IM
MH  - Aging/*metabolism
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Denervation/adverse effects
MH  - Glial Cell Line-Derived Neurotrophic Factor
MH  - Male
MH  - Neostriatum/cytology/*metabolism
MH  - *Nerve Growth Factors
MH  - Nerve Regeneration/*physiology
MH  - Nerve Tissue Proteins/*metabolism
MH  - Neural Pathways/cytology/metabolism
MH  - Neuronal Plasticity/physiology
MH  - Neurotoxins/pharmacology
MH  - Neurotrophin 3/*metabolism
MH  - Oxidopamine/pharmacology
MH  - Rats
MH  - Recovery of Function/physiology
MH  - Substantia Nigra/cytology/*metabolism
EDAT- 2001/02/13 11:00
MHDA- 2001/05/22 10:01
CRDT- 2001/02/13 11:00
PHST- 2001/02/13 11:00 [pubmed]
PHST- 2001/05/22 10:01 [medline]
PHST- 2001/02/13 11:00 [entrez]
AID - S0006-8993(00)03217-0 [pii]
AID - 10.1016/s0006-8993(00)03217-0 [doi]
PST - ppublish
SO  - Brain Res. 2001 Feb 9;891(1-2):228-35. doi: 10.1016/s0006-8993(00)03217-0.