PMID- 11164993
OWN - NLM
STAT- MEDLINE
DCOM- 20010329
LR  - 20190819
IS  - 0300-483X (Print)
IS  - 0300-483X (Linking)
VI  - 158
IP  - 1-2
DP  - 2001 Feb 2
TI  - The local lymph node assay and potential application to the identification of 
      drug allergens.
PG  - 59-64
AB  - The local lymph node assay (LLNA) is a method for the identification of skin 
      sensitization hazard. The method is based upon measurement of proliferative 
      responses induced in draining lymph nodes following topical exposure of mice to 
      the test chemical. More recently the LLNA has also been used for the evaluation 
      of relative skin sensitization potency in the context of risk assessment. 
      Idiosyncratic drug reactions resulting from the stimulation of allergic or 
      autoimmunogenic responses are poorly understood but represent an important 
      clinical problem. In this article, the potential utility of the LLNA, either in a 
      conventional modified configuration, to provide information of value in 
      assessment the potential for systemic allergenicity is considered.
FAU - Kimber, I
AU  - Kimber I
AD  - Zeneca Central Toxicology Laboratory, Alderley Park, Macclesfield, SK10 4TJ, 
      Cheshire, UK.ian.kimber@CTL.Zeneca.com
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Ireland
TA  - Toxicology
JT  - Toxicology
JID - 0361055
RN  - 0 (Allergens)
SB  - IM
MH  - Allergens/*toxicity
MH  - Animals
MH  - Dermatitis, Allergic Contact/*etiology
MH  - Drug Evaluation, Preclinical
MH  - Drug Hypersensitivity/*etiology/immunology/pathology
MH  - *Local Lymph Node Assay
MH  - Lymph Nodes/*drug effects/immunology/pathology
MH  - Lymphocyte Activation/drug effects
MH  - Mice
MH  - Mice, Inbred CBA
RF  - 43
EDAT- 2001/02/13 11:00
MHDA- 2001/04/03 10:01
CRDT- 2001/02/13 11:00
PHST- 2001/02/13 11:00 [pubmed]
PHST- 2001/04/03 10:01 [medline]
PHST- 2001/02/13 11:00 [entrez]
AID - S0300-483X(00)00408-X [pii]
AID - 10.1016/s0300-483x(00)00408-x [doi]
PST - ppublish
SO  - Toxicology. 2001 Feb 2;158(1-2):59-64. doi: 10.1016/s0300-483x(00)00408-x.