PMID- 11165317
OWN - NLM
STAT- MEDLINE
DCOM- 20010301
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 124
IP  - 1
DP  - 2001 Jan 1
TI  - Nonrandom chromosome changes in Kaposi sarcoma: cytogenetic and FISH results in a 
      new cell line (KS-IMM) and literature review.
PG  - 16-9
AB  - The karyotype of a new tumorigenic Kaposi sarcoma (KS)-derived cell line, as 
      defined by cytogenetic and fluorescence in situ hybridization (FISH) analysis is 
      49,XY,i(1)(q10),i(7)(p10),+i(7) 
      (q10),+der(8)t(8;13)(p11;q11),-13,+del(14)(q22),+der(17)t(1;17)(p13;p13). Our aim 
      was to point out some characteristics and recurrent chromosome changes probably 
      playing a relevant role in the malignant progression of KS, by a comparison of 
      the cytogenetic results obtained in the present study with data from the 
      literature. The interpretation of the cytogenetic results is that KS development 
      occurs by multiple steps: an initial reactive polyclonal cell proliferation is 
      associated with chromosome instability; the cells in a later stage acquire clonal 
      chromosome changes. If many chromosome changes are present, particularly 8q and 
      1q trisomy, 3p14-->pter deletion, 1p13, 13p14.3, 7q22, 8p11, 13q11, and 19q13 
      band rearrangements, KS acquires a neoplastic aggressive state.
FAU - Casalone, R
AU  - Casalone R
AD  - Laboratorio di Citogenetica e Genetica, Ospedale di Circolo e Universita 
      dell'Insubria, Viale Borri 57, 21100, Varese, Italy. rosario_c@iol.it
FAU - Albini, A
AU  - Albini A
FAU - Righi, R
AU  - Righi R
FAU - Granata, P
AU  - Granata P
FAU - Toniolo, A
AU  - Toniolo A
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Chromosome Aberrations/*genetics
MH  - Humans
MH  - Iatrogenic Disease
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Ploidies
MH  - Sarcoma, Kaposi/*genetics
MH  - *Tumor Cells, Cultured
RF  - 6
EDAT- 2001/02/13 11:00
MHDA- 2001/03/07 10:01
CRDT- 2001/02/13 11:00
PHST- 2001/02/13 11:00 [pubmed]
PHST- 2001/03/07 10:01 [medline]
PHST- 2001/02/13 11:00 [entrez]
AID - S0165-4608(00)00241-7 [pii]
AID - 10.1016/s0165-4608(00)00241-7 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2001 Jan 1;124(1):16-9. doi: 
      10.1016/s0165-4608(00)00241-7.