PMID- 11165318
OWN - NLM
STAT- MEDLINE
DCOM- 20010301
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 124
IP  - 1
DP  - 2001 Jan 1
TI  - Two putative tumor suppressor genes on chromosome arm 8p may play different roles 
      in prostate cancer.
PG  - 20-6
AB  - Although loss of heterozygosity (LOH) on the short arm of chromosome 8 has been 
      frequently observed in human prostate cancer, the relationship between LOH and 
      clinical background is poorly understood. Fluorescence in situ hybridization 
      (FISH) was employed to evaluate the chromosomal deletion on 8p in 42 prostate 
      cancers using a centromeric probe for chromosome 8, in combination with 4 cosmid 
      probes spanning 8p12 to 8p22. Deletions for at least one locus on the 8p were 
      observed in 29 (69.0%) tumors. The most frequently deleted regions were 8p22 
      (54.8%) and 8p21.3 (52.4%), in almost the same frequency. The second most 
      frequently deleted region was 8p21.1-p21.2 (38.1%). Deletions of 8p22 and 8p21.3 
      significantly correlated with tumor grade (P=0.0034, Fisher's exact probability 
      test). A significantly higher frequency of the deletion on 8p21.1-p21.2 was 
      observed in advanced prostate cancer (beyond capsular penetration or positive 
      nodal metastases) than in localized prostate cancer (P=0.0033). In particular, 
      deletion of 8p21.1-p21.2 was more frequently observed in the cases with lymph 
      node metastases than without them (P=0.0029). No clinicopathological parameters 
      had significant relation to deletions on 8p12. These results suggest that 
      deletions on 8p22-p21.3 play an important role in tumor differentiation, while an 
      8p21.1-p21.2 deletion plays a role in the progression of prostate cancer.
FAU - Oba, K
AU  - Oba K
AD  - Department of Urology, Yamaguchi University School of Medicine, 1-1 
      Minami-Kogushi, Ube, Japan.
FAU - Matsuyama, H
AU  - Matsuyama H
FAU - Yoshihiro, S
AU  - Yoshihiro S
FAU - Kishi, F
AU  - Kishi F
FAU - Takahashi, M
AU  - Takahashi M
FAU - Tsukamoto, M
AU  - Tsukamoto M
FAU - Kinjo, M
AU  - Kinjo M
FAU - Sagiyama, K
AU  - Sagiyama K
FAU - Naito, K
AU  - Naito K
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Chromosome Aberrations/genetics
MH  - *Chromosome Deletion
MH  - Chromosome Mapping
MH  - Chromosomes, Human, Pair 8/*genetics/physiology
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Prostatic Neoplasms/*genetics/pathology
EDAT- 2001/02/13 11:00
MHDA- 2001/03/07 10:01
CRDT- 2001/02/13 11:00
PHST- 2001/02/13 11:00 [pubmed]
PHST- 2001/03/07 10:01 [medline]
PHST- 2001/02/13 11:00 [entrez]
AID - S0165-4608(00)00248-X [pii]
AID - 10.1016/s0165-4608(00)00248-x [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2001 Jan 1;124(1):20-6. doi: 
      10.1016/s0165-4608(00)00248-x.