PMID- 11168339
OWN - NLM
STAT- MEDLINE
DCOM- 20010503
LR  - 20190831
IS  - 0742-3071 (Print)
IS  - 0742-3071 (Linking)
VI  - 18
IP  - 1
DP  - 2001 Jan
TI  - Maximal post-prandial triglyceride increase reflects post-prandial 
      hypertriglyceridaemia and is associated with the insulin resistance syndrome.
PG  - 32-9
AB  - AIMS: To assess the value of maximal post-prandial triglyceride increase after a 
      high fat, low carbohydrate (CHO) test meal, as index of post-prandial 
      hypertriglyceridaemia and its relation with insulin resistance. METHODS: Fifty 
      non-diabetic subjects, 22 male and 28 female, aged 52.1+/-4.5 and 56.9+/-3.8 
      years, were studied. Glucose, insulin and triglycerides were measured fasting and 
      1, 2, 3 and 4 h after a meal consisting of 40 g fat, 19 g protein and 10 g CHO. 
      Insulin resistance was calculated according to the HOMA model. RESULTS: The 
      maximal triglyceride increment occurred during the 4th hour. Its absolute value 
      (delta-TG) and the per cent increase over the fasting value (PTI), were 
      considered appropriate for the evaluation of the post-prandial triglyceride 
      response. Both delta-TG and PTI were strongly correlated with triglycerides 
      incremental area in males and females, r = 0.797 and r = 0.700, P<0.01 and r = 
      0.805 and r = 0.774, P<0.001, respectively, and thus they can be used as indices 
      of the post-prandial triglyceride response. No correlation was found between 
      fasting triglyceride and triglyceride incremental area or delta-TG. Thus, 
      post-prandial hypertriglyceridaemia can occur irrespectively of the fasting 
      triglyceride concentrations. A weak correlation was found between PTI and insulin 
      resistance in females, r = 0.384, P<0.05, but not in males, r = 0.224, P>0.05. 
      However further analysis by quartiles of PTI showed similar insulin resistance 
      levels in the first three quartiles and a significant increase in the 4th, both 
      for males and females, 4th vs. 3rd quartile 7.4+/-3.6 vs. 2.2+/-0.7 and 6.4+/-2.4 
      vs. 2.2+/-0.6, respectively. The 4th quartile corresponds to a PTI > or =80%. 
      CONCLUSIONS: PTI after the high fat, low CHO test meal used, consistently 
      reflects post-prandial hypertriglyceridaemia, is easily measured and it is not 
      predicted by fasting triglycerides. A PTI > or = 80% is associated with a 
      significant increase of insulin resistance, and might therefore be considered the 
      cut-off point for an abnormal post-prandial hypertriglyceridaemic response, at 
      least in relation with insulin resistance. Such response could be added to the 
      abnormalities of the insulin resistance syndrome, as an independent parameter.
FAU - Karamanos, B G
AU  - Karamanos BG
AD  - Diabetes Center, 2nd Medical Department, Athens University, Hippokration 
      Hospital, Greece. ippokratio@aias.net
FAU - Thanopoulou, A C
AU  - Thanopoulou AC
FAU - Roussi-Penesi, D P
AU  - Roussi-Penesi DP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Diabet Med
JT  - Diabetic medicine : a journal of the British Diabetic Association
JID - 8500858
RN  - 0 (Blood Glucose)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Dietary Fats)
RN  - 0 (Insulin)
RN  - 0 (Triglycerides)
SB  - IM
MH  - Blood Glucose/metabolism
MH  - Body Mass Index
MH  - Dietary Carbohydrates
MH  - Dietary Fats
MH  - Fasting
MH  - Female
MH  - Homeostasis
MH  - Humans
MH  - Hypertriglyceridemia/blood/*physiopathology
MH  - Insulin/blood
MH  - Insulin Resistance/*physiology
MH  - Male
MH  - Middle Aged
MH  - Models, Biological
MH  - Postprandial Period
MH  - Regression Analysis
MH  - Sex Characteristics
MH  - Time Factors
MH  - Triglycerides/*blood
EDAT- 2001/02/13 11:00
MHDA- 2001/05/05 10:01
CRDT- 2001/02/13 11:00
PHST- 2001/02/13 11:00 [pubmed]
PHST- 2001/05/05 10:01 [medline]
PHST- 2001/02/13 11:00 [entrez]
AID - dme386 [pii]
AID - 10.1046/j.1464-5491.2001.00386.x [doi]
PST - ppublish
SO  - Diabet Med. 2001 Jan;18(1):32-9. doi: 10.1046/j.1464-5491.2001.00386.x.