PMID- 11168544
OWN - NLM
STAT- MEDLINE
DCOM- 20010510
LR  - 20161124
IS  - 0953-816X (Print)
IS  - 0953-816X (Linking)
VI  - 13
IP  - 2
DP  - 2001 Jan
TI  - Central forebrain Fos responses to familiar male odours are attenuated in 
      recently mated female mice.
PG  - 389-99
AB  - Exposure of recently mated female mice to the urinary odours of an unfamiliar 
      male blocks pregnancy (the Bruce effect). The absence of a pregnancy block in 
      response to the stud male's familiar odours depends on an olfactory memory that 
      is formed in the accessory olfactory bulb (AOB) in response to vomeronasal organ 
      (VNO) inputs during mating. Sexually naive Balb/c female mice in 
      pro-oestrus/oestrus were either placed onto soiled bedding ('bedding-only' 
      females) from, or allowed to mate with, a Balb/c male ('recently mated' females). 
      After 42 h, females were placed for 90 min onto clean bedding (controls) or onto 
      soiled bedding from either a C57BL/6 male (unfamiliar bedding) or a Balb/c male 
      (familiar bedding). Significant increases in Fos-immunoreactivity (Fos-IR, a 
      marker of neuronal activation) occurred in the medial amygdala and the medial 
      preoptic area (MPA) of 'bedding only' females exposed to either unfamiliar or 
      familiar bedding and in 'recently mated' females exposed to unfamiliar bedding 
      but not to familiar bedding. This suggests that a mating-induced memory prevents 
      the later activation by the familiar stud male's odours of neurons in forebrain 
      regions that receive inputs from the VNO--AOB. 'Bedding-only' females later 
      exposed to either familiar or unfamiliar bedding had increased Fos-IR in the G 
      alpha(o) protein-expressing basal zone of the VNO whereas no such effect occurred 
      in 'recently mated' females. Familiar, as well as unfamiliar, male odours 
      augmented Fos-IR in significantly more rostral than caudal AOB granule cells in 
      all groups, with the effect being strongest in 'recently mated' females exposed 
      to familiar male bedding. This outcome is consistent with the absence of 
      odour-induced Fos-IR in forebrain regions of these females and, presumably, the 
      absence of a pregnancy block.
FAU - Halem, H A
AU  - Halem HA
AD  - Department of Biology, Boston University, Boston, MA 02215, USA.
FAU - Cherry, J A
AU  - Cherry JA
FAU - Baum, M J
AU  - Baum MJ
LA  - eng
GR  - DC03019/DC/NIDCD NIH HHS/United States
GR  - MH59200/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - France
TA  - Eur J Neurosci
JT  - The European journal of neuroscience
JID - 8918110
RN  - 0 (Proto-Oncogene Proteins c-fos)
RN  - 0 (Sex Attractants)
SB  - IM
MH  - Animals
MH  - Copulation/physiology
MH  - Female
MH  - Immunohistochemistry
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Neurons
MH  - Odorants
MH  - Olfactory Bulb/chemistry/*physiology
MH  - Olfactory Mucosa/chemistry/physiology
MH  - Olfactory Pathways/chemistry/*physiology
MH  - Proto-Oncogene Proteins c-fos/analysis
MH  - *Sex Attractants
MH  - Smell/*physiology
MH  - Vomeronasal Organ/chemistry/*physiology
EDAT- 2001/02/13 11:00
MHDA- 2001/05/22 10:01
CRDT- 2001/02/13 11:00
PHST- 2001/02/13 11:00 [pubmed]
PHST- 2001/05/22 10:01 [medline]
PHST- 2001/02/13 11:00 [entrez]
AID - ejn1382 [pii]
PST - ppublish
SO  - Eur J Neurosci. 2001 Jan;13(2):389-99.