PMID- 11170290
OWN - NLM
STAT- MEDLINE
DCOM- 20010412
LR  - 20061115
IS  - 1045-2257 (Print)
IS  - 1045-2257 (Linking)
VI  - 30
IP  - 3
DP  - 2001 Mar
TI  - Supernumerary ring chromosome in a Bednar tumor (pigmented dermatofibrosarcoma 
      protuberans) is composed of interspersed sequences from chromosomes 17 and 22: a 
      fluorescence in situ hybridization and comparative genomic hybridization 
      analysis.
PG  - 305-9
AB  - Cytogenetic analysis of Bednar tumor (pigmented dermatofibrosarcoma protuberans) 
      has not been reported previously. Here, we report the identification of a 
      supernumerary ring chromosome in a Bednar tumor by chromosome painting with 
      fluorescence in situ hybridization (FISH) and comparative genomic hybridization 
      (CGH). Chromosome painting with FISH demonstrated that the supernumerary ring 
      chromosome was composed of discontinuous, interwoven sequences from chromosomes 
      17 and 22. Amplification of chromosomes 17 and 22 sequences was confirmed by CGH. 
      These results indicate that Bednar tumor and dermatofibrosarcoma protuberans are 
      characterized by the same chromosomal features. To our knowledge, this is the 
      first report that the ring chromosome in Bednar tumor is composed of amplified 
      material from chromosomes 17 and 22.
CI  - Copyright 2001 Wiley-Liss, Inc.
FAU - Nishio, J
AU  - Nishio J
AD  - Department of Pathology, School of Medicine, Fukuoka University, Japan.
FAU - Iwasaki, H
AU  - Iwasaki H
FAU - Ishiguro, M
AU  - Ishiguro M
FAU - Ohjimi, Y
AU  - Ohjimi Y
FAU - Yo, S
AU  - Yo S
FAU - Isayama, T
AU  - Isayama T
FAU - Naito, M
AU  - Naito M
FAU - Kikuchi, M
AU  - Kikuchi M
LA  - eng
PT  - Case Reports
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Genes Chromosomes Cancer
JT  - Genes, chromosomes & cancer
JID - 9007329
SB  - IM
MH  - Chromosome Banding
MH  - Chromosome Painting
MH  - Chromosomes, Human, Pair 17/*genetics
MH  - Chromosomes, Human, Pair 22/*genetics
MH  - Dermatofibrosarcoma/*genetics
MH  - Humans
MH  - *In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Male
MH  - Middle Aged
MH  - Nucleic Acid Hybridization
MH  - *Ring Chromosomes
MH  - Skin Neoplasms/*genetics
EDAT- 2001/02/15 11:00
MHDA- 2001/04/17 10:01
CRDT- 2001/02/15 11:00
PHST- 2001/02/15 11:00 [pubmed]
PHST- 2001/04/17 10:01 [medline]
PHST- 2001/02/15 11:00 [entrez]
AID - 10.1002/1098-2264(200103)30:3<305::AID-GCC1091>3.0.CO;2-U [pii]
PST - ppublish
SO  - Genes Chromosomes Cancer. 2001 Mar;30(3):305-9.